Molecular therapy for TIIDM and obesity-associated metabolic deficits: Duloxetine (Trade name: Cymbalta), an anti-anxiety drug,  increases Lipocalin 2 (LCN2) expression, activates an MC4R-dependent anorexigenic pathway, suppresses appetite and weight gain, increases insulin secretion, improves glucose tolerance, promotes glucose homeostasis, improves obesity-associated metabolic deficits and prevents progression to TIIDM via down regulation of its target gene, 28/September/2017, 5.30 am

Introduction: What they say A study from the Department of Physiology-Cellular Biophysics, College of Physicians and Surgeons, Columbia University, New York, New York, USA shows that “MC4R-dependent suppression of appetite by bone-derived lipocalin 2.” This research paper, was published in the 8 March 2017 issue of the journal “Nature” [One of the best research journals […]

Natural product-derived regenerative therapy for muscular atrophy: Oligonol, isolated from Lychee,  increases the expression of IGF-1, PI3K(p85a) and B-Myb, decreases the expression of tumor suppressors, promotes regeneration of muscle cells, and reverses muscle atrophy via up regulation of its target gene, 28/September/2017, 5.17 am

Introduction: What they say A study from the Cardiac Regeneration and Ageing Lab, School of Life Science, Shanghai University, Shanghai, China shows that “miR-29b contributes to multiple types of muscle atrophy.” This research paper was published, in the 25 May 2017 issue of the journal “Nature communications” [One of the best research journals in Science with an I.F of 11.329 ], by Prof. Xiao […]

 Natural product therapy for pulmonary arterial hypertension: Oleanolic acid, isolated from Olive oil, and Jawa apple, among others, inhibits the development of pulmonary arterial hypertension via down regulation of its target gene Notch3, 28/September/2017, 5. 06 am

What they say:  A study from the University of California, La Jolla, California, USA shows that “Notch3 signaling promotes the development of pulmonary arterial hypertension.” This study was published, in the 15 November  2009 issue of the journal “Nature Medicine”[the number 1 journal in General Medicine with an I.F of 28.054], by Prof. Thistlethwaite PA, Li X and others. What we say:  On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief […]

Natural product-based therapy for TIIDM and obesity-associated metabolic deficits: Teasaponin, isolated from camellia sinesis, increases Lipocalin 2 (LCN2) expression, activates an MC4R-dependent anorexigenic pathway, suppresses appetite and weight gain, increases insulin secretion, improves glucose tolerance, promotes glucose homeostasis, improves obesity-associated metabolic deficits and prevents progression to TIIDM via down regulation of its target gene, 27/September/2017, 1.24 am

Introduction: What they say A study from the Department of Physiology-Cellular Biophysics, College of Physicians and Surgeons, Columbia University, New York, New York, USA shows that “MC4R-dependent suppression of appetite by bone-derived lipocalin 2.” This research paper was published, in the 8 March 2017 issue of the journal “Nature” [One of the best research journals […]

 Natural product-based combinatorial therapy for Lifespan extension: A therapeutic mix encompassing Catalpol, Cholecalciferol, Maresin, Ursolic acid, DIM, Nordihydroguaiaretic acid (NDGA), & Lutein   (CCMUDNL) activates autophagy, promotes leanness, increases insulin sensitivity, improves motor function, alleviates ageing feature and extends lifespan via up regulation of its target gene ATG5 (Autophagy related 5) , 27/September/2017, 1.04 am

Introduction: What they say A study from the Global Research Laboratory, Seoul National University, Korea shows that “Overexpression of Atg5 in mice activates autophagy and extends lifespan.” This study was published, in the online journal “Nature communications”,  by Prof. Jung YK, Pyo Jo and others. Earlier, Prof. Yoshinori Ohsumi, from Institute of Innovative Research, Tokyo Institute of Technology, who won the Nobel […]

Natural product-based Anti-ageing and Life extension therapy:  A pharmaceutical mixture encompassing Magnolol, Garcinol, EPC-K1, Hesperitin, & Cholecalciferol (MGEHC) increases CHIP levels, increases monoubiquitylation of insulin receptor (INSR), decreases INSR protein levels and enhances lifespan via down regulation of its target gene, 27/September/2017, 12.14 am

Introduction: What they say A study from Institute for Cell Biology, University of Bonn, Ulrich-Haberland Str.  Bonn, Germany; and Institute for Genetics and CECAD Research Center, University of Cologne, Joseph-Stelzmann Str. Cologne, Germany shows that “The Ubiquitin Ligase CHIP Integrates Proteostasis and Aging by Regulation of Insulin Receptor Turnover.” This research paper was published, in […]