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November 1, 2017

Natural product-derived therapy for inflammation and arthritis: Icariin, isolated from Epimedium/horny goat weed, increases IL-9 levels, increases proliferation of ILC2s (type 2 innate lymphoid cells) and regulatory T (Treg) cells, promotes resolution of inflammation, attenuates cartilage destruction, decreases bone loss, and inhibits pathological features associated with arthritis via up regualtion of its target genes, 1/November/2017, 11.48 pm

Introduction: What they say A study from Department of Internal Medicine 3-Rheumatology and Immunology, Friedrich Alexander University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen, Erlangen, Germany shows that […]
November 1, 2017

Lifespan extension therapy:  4-Hydroxyderricin (4-HD), isolated from Ashitaba (Angelica Keiskei), increases life span via up-regulation of its target gene BubR1, 1/November/2017, 11.41 pm

 What they say: Introduction:  A recent study from the Department of Genetics, Paul F. Glenn Laboratories for the Biological Mechanisms of Aging Harvard Medical School, Boston,USA; and […]
November 1, 2017

Natural product therapy for Non-alcoholic fatty liver disease (NAFLD): β-Cryptoxanthin (βCX) promotes degradation of HMGCR, decreases the levels of triglycerides, free cholesterol, and total cholesterol and prevents the progression of Non-alcoholic fatty liver disease (NAFLD via down regulation of its target gene, 1/November/2017, 11.33 pm

Significance of the study: Given that: (1)  15-30% of Western populations suffer from Non-alcoholic fatty liver disease (NAFLD), while 6-25% of Asian populations suffer from it; (2) 75 to […]
October 31, 2017

Molecular therapy for muscle atrophy and wasting:Rivaroxaban (Trade name: Xarelto), an anticoagulant (blood thinner), increases the expression of FGF19 and its receptor ß-Klotho, phosphorylates ERK1/2 and S6K1, decreases the expression of tumor suppressors  genes, promotes regeneration of muscle cells and hypertrophy of skeletal muscle, and reverses muscular atrophy and wasting via up regulation of its target gene, 1/November/2017, 4.33 am

Introduction: What they say A study from Department of Biology, University of Bergen, Bergen, Norway; and Univ-Lyon, CarMeN Laboratory, INSERM 1060, INRA 1397, Université Claude Bernard Lyon, INSA Lyon, Oullins, France […]
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