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August 23, 2017

Natural product-derived combinatorial therapy for therapy-resistant cancers: A therapeutic mix encompassing Berberine (BER), Gambogic acid and Curcumin (BGC) inhibits the expression of phospholipid glutathione peroxidase (GPX4), inhibits GPX4 signaling network and lipid peroxidase pathway, suppresses EMT protein ZEB1, increases sensitivity to anticancer therapy and prolongs survival via up regulation of its target gene, 24/August/2017, 12.33 am

Introduction: What they say: A study from Broad Institute, Cambridge, Massachusetts, USA, Howard Hughes Medical Institute, Chevy Chase, Maryland and Department of Chemistry and Chemical Biology, […]
August 23, 2017

Molecular therapy for Metastatic cancers: Myrtenal, isolated  from Taxus, increases the expression of metastasis suppressors TIMP3 and CCM3/KRTI1, inhibits cell cycle progression, and suppresses migration, invasion and metastasis of cancer cells via up regulation of its target gene, 24/August/2017, 12.24 am

From Significance of the study to Public health relevance: Given that: (i) each year nearly 14 million people are diagnosed with cancer globally, and little more […]
August 23, 2017

Natural product-derived therapy for inflammation and arthritis: β-Cryptoxanthin, isolated from Satsuma Mandarin, Buah Merah, Papaya and Paparika among others, increases IL-9 levels, increases proliferation of ILC2s (type 2 innate lymphoid cells) and regulatory T (Treg) cells, promotes resolution of inflammation, attenuates cartilage destruction, decreases bone loss, and inhibits pathological features associated with arthritis via up regualtion of its target genes, 24/August/2017, 12.14 am

Introduction: What they say A study from Department of Internal Medicine 3-Rheumatology and Immunology, Friedrich Alexander University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen, Erlangen, Germany shows that […]
August 22, 2017

Natural product-derived Lifespan extension therapy: Geniposide(GP), isolated from Gardenia,  prolongs mammalian life span via down regulation of angiotensin II type I receptor (AT1R), 23/August/2017, 12.11 am

Significance of the study: It has been shown earlier that antagonizing angiotensin II type I receptor (AT1R) expression may prolong mammalian life span. Further, it has been shown […]
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