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March 9, 2020

Repurposing the anti-cancer agent Imatinib into an anti-HIV agent: Imatinib (trade name: Gleevec, Glivec and others) increases Heme oxygenase 2 (HO-2) expression, blocks N-myristoylation of HIV-1 Gag protein, disrupts HIV-1 budding, and restricts HIV-1 production, via upregulation of its target gene, 9/March/2020, 11.23 pm

What we say: Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Repurposing the anti-cancer agent Imatinib into an anti-HIV agent: Imatinib (trade name: Gleevec, […]
March 9, 2020

Curing, preventing and reversing diabetes with a commonly available antiasthmatic drug Montelukast: Montelukast-based therapy for TIIDM and obesity-associated metabolic deficits: Montelukast (trade name: Singulair and others), a vasodilator used in the treatment of asthma, increases Lipocalin 2 (LCN2) expression, activates an MC4R-dependent anorexigenic pathway, decreases TXNIP expression, suppresses appetite and weight gain, increases insulin secretion, improves glucose tolerance, promotes glucose homeostasis, improves obesity-associated metabolic deficits and prevents progression to TIIDM, via down-regulation of its target gene, 9/March/2020, 11.08 pm

Introduction: What they say A study from the Department of Physiology-Cellular Biophysics, College of Physicians and Surgeons, Columbia University, New York, New York, USA shows that “MC4R-dependent […]
March 1, 2020

Repurposing the anti-allergic drug into a cardioprotective drug: Tranilast-based Regenerative therapy for regaining the lost cardiomyocytes in Myocardial patients: Tranilast, an anti-allergy drug increases the expression of ERBB2/Her2 and promotes dedifferentiation  of cardiomyocytes, via up-regulation of its target gene, 1/March/2020, 5.43 pm

Introduction: What they say A recent study from the Department of Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel shows that “ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte dedifferentiation and proliferation.” This study was […]
February 28, 2020

Mechanistic insights into how Vitamin C/Ascorbic acid enhances immunity against bacterial infections: Ascorbic acid-based immune enhancement therapy: Ascorbic acid increases SOX2 expression, and promotes innate immunity against bacterial infection, via down-regulation of its target gene, 28/February/2020, 10.27 am

National Science day special ********* We wish everyone a very happy national science day. On this special occasion, we are happy to announce that Bio-Med/Pharma/Therapeutic/Clinical ideas posted […]
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