Molecular therapy for glioblastoma: MiRNA-766  inhibits the expression of JMJD6, impairs functioning of transcription elongation machinery, inhibits the proliferation of glioblastoma cells, suppresses tumor cell migration, reduces metastasis and prolongs survival via down regulation of its target gene, 28/July/2017,  10.57 pm

Introduction: What they say: A study from the Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Ohio, USA shows that “Transcription elongation factors represent in vivo cancer dependencies in glioblastoma.” This study was published, in the 5 July 2017 issue of the journal “Nature” [One of the best journals in Science with an I.F of 43 plus], by Prof.Rich JN, Miller […]

Natural product-derived therapy for glucose homeostasis and TIIDM: β-Cryptoxanthin, isolated from sweet peppers, increases Barr2 expression, augments the functional activity of CAMKII, increases insulin secretion, promotes glucose homeostasis, prevents progression to TIIDM and ameliorates obesity-associated metabolic deficits via down regulation of its target gene, 28/July/2017, 10.12 pm

Introduction: What they say A study from the Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892, USA shows that “ß-arrestin-2 is an essential regulator of pancreatic ß-cell function under physiological and pathophysiological conditions.” This research paper was published in the 1 February 2017 issue […]

Natural product therapy for glucose homeostasis and TIIDM: Artemether, a derivative of Artemisinin isolated from Artemesia Annua L,   increases Pax6 and insulin expression, decreases the levels of glucagon, ghrelin and Somatostatin, reduces metabolic stress, improves insulin sensitivity, promotes glucose homeostasis and prevents progression to TIIDM via down regulation of its target gene, 28/July/2017, 10.00 pm

Introduction: What they say A study from the Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem, Israel shows that “PAX6 maintains ß cell identity by repressing genes of alternative islet cell types.” This research paper was published in the 12 December 2016 issue of the journal “Journal of Clinical investigations” [One […]

Molecular-therapy for Regenerating the lost pancreatic β-cells in Diabetic patients:  Beraprost Sodium increases the expression of IGF1R, INSR, and IRS2, and promotes an insulin-sensitized state via up-regulation of  its target gene Lin28, 28/July/2017, 9.52 pm

Introduction: What they say:   A study from the Stem Cell Transplantation Program, Division of Pediatric Hematology/Oncology, Boston Children’s Hospital and Dana-Farber Cancer Institute, Boston, Massachusetts, USA shows that “The Lin28/let-7 axis regulates glucose metabolism.” This study was published in the 30 September  2011 issue of the Journal “Cell” [One of the best journals in Biological sciences with an I.F of 28.71]  by Prof and Dean of the Harvard […]

Combinatorial therapy for body weight control, energy homeostasis and TIIDM: A therapeutic mix encompassing Arctigenin and AICAR decreases CADM1 and its downstream target genes that promote glucose-induced insulin secretion, improves insulin sensitivity, increases energy utilization, promotes weight loss and protects from diet-induced obesity and TIIDM via up regulation of its target gene, 28/July/2017, 12.05 am

Introduction: What they say A study from the Max Delbrück Center for Molecular Medicine, Berlin, Germany shows that “Regulation of body weight and energy homeostasis by neuronal cell adhesion molecule1.” This research paper was published, in the June 2017 issue of the journal “Nature Neuroscience” [One of the best research journals in Neuroscience with an I.F of 17.398], by Prof. […]

Natural product-derived antiviral therapy for HIV virus: Artemisinin, isolated from Artemesia Annua L,  increases Heme oxygenase 2 (HO-2) expression, blocks N-myristoylation of HIV-1 Gag protein, disrupts HIV-1 budding, and restricts HIV-1 production via up regulation of its target gene, 27/July/2017, 11.15 pm

What we say: Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-derived antiviral therapy for HIV virus: Artemisinin, isolated from Artemesia Annua L,  increases Heme oxygenase 2 (HO-2) expression, blocks N-myristoylation of HIV-1 Gag protein, disrupts HIV-1 budding, and restricts HIV-1 production via up regulation of its target gene [easy_payment currency=”USD”] From Significance […]