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July 25, 2017

Natural product-derived Ptpn2 pathway blockade enhances the efficacy of Cancer immunotherapy: Honokiol, isolated from Magnolia grandiflora, inhibits the expression of protein tyrosine phosphatase PTPN2, increases interferon-IFNγ signalling, augments antigen presentation and unfolding response, increases Cytotoxic activity of T-cells, decreases tumor burden and increases survival via up-regulation of its target gene, 25/July/2017, 2.23 pm

Introduction:What they say: A recent study from Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA; Broad Institute of Harvard and Massachusetts Institute of […]
July 25, 2017

The PD-1 pathway activation for Pain therapy: Ursodeoxycholic acid  increases the expression of PD-L1, attenuates acutes and chronic pain, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability via up-regulation of its target gene, 25/July/2017, 12.26  pm

Introduction:What they say: A recent study from Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center for Brain […]
July 25, 2017

Amino acid therapy for Diabetic nephropathy (DN): Taurine ( amino sulfonic acid), the most abundant amino acid, increases Pyruvate kinase M2 (PKM2) expression, decreases toxic glucose metabolites, mitochondrial dysfunction and apoptosis, augments glycolytic flux and PGC-1α levels, improves metabolic abnormalities, albuminuria, glomerular pathology, and renal dysfunction and alleviates diabetic nephropathy via down regulation of its target gene, 25/July/2017, 11.51 am

Introduction: What they say A study from the Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, USA shows that “Pyruvate kinase M2 activation may protect against the […]
July 25, 2017

 Hyperbaric oxygen (HBO2)-based therapy for Stroke: Hyperbaric oxygen (HBO2) attenuates hippocampal neurons injury, augments regenerative neurogenesis after Ischemic Stroke, and ameliorates stroke damage and neurological deficits via up regulation of its target genes BDNF and NAMPT., 25/July/2017, 11.38 am

Introduction: What they say A recent study from Research Center for Neurobiology and Department of Neurobiology, Xuzhou Medical College, 209 Tongshan Road, Xuzhou, Jiangsu 221004, PR China; and […]
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