Life-extension therapy: Kallistatin inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 31/May/2017, 10.07 pm

What they say?  A study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.” This study was published in the 2 October 2009 issue of the Journal “Science” (I.F: 31.477 ) by Prof Dominic J. Withers, Dr. Selman C and others. What we […]

Natural product-based Anti-ageing and Life extension therapy: Hesperidin, isolated from Peppermint and Blood orange, increases CHIP levels, increases monoubiquitylation of insulin receptor (INSR), decreases INSR protein levels and enhances lifespan via down regulation of its target gene, 30/May/2015, 11.07 pm

Introduction: What they say A study from Institute for Cell Biology, University of Bonn, Ulrich-Haberland Str.  Bonn, Germany; and Institute for Genetics and CECAD Research Center, University of Cologne, Joseph-Stelzmann Str. Cologne, Germany shows that “The Ubiquitin Ligase CHIP Integrates Proteostasis and Aging by Regulation of Insulin Receptor Turnover.” This research paper was published, in […]

Narrow-band ultraviolet B-based regenerative therapy for improving memory in aged individuals:Narrow-band ultraviolet B therapy increases Tissue inhibitor of metalloproteinases 2 (TIMP2) levels, improves cognition, and decreases age-associated decline in memory and learning via down regulation of its target genes, 30/May/2017, 11.06 pm

Introduction: What they say A study from Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA;  Paul F. Glenn Center for the Biology of Aging, Stanford University School of Medicine, Stanford, California 94305, USA Neuroscience Graduate Program, Stanford University School of Medicine, Stanford, California, USA; Center for Tissue Regeneration, Repair […]

Lifespan extension therapy: Kallistatin prolongs mammalian life span via down regulation of angiotensin II type I receptor (AT1R), 30/May/2017, 11.03 pm

Significance of the study: It has been shown earlier that antagonizing angiotensin II type I receptor (AT1R) expression may prolong mammalian life span. Further, it has been shown that disruption of AT1R (AGTR1) gene results in marked prolongation of mammalian lifespan.  From research findings to therapeutic opportunity:  This study suggests, for the first time, that Kallistatin, by increasing the […]

Vitamin-based therapy for Chronic Myeloid leukaemia (CML): Cholecalciferol, a form of Vitamin-D3, decreases the expression of Musashi2, inhibits cytosolic aminotransferase BCAT1 expression, decreases the intracellular production of BCAAs (Branched-chain amino acids), increases the expression of tumor suppressor genes, promotes differentiation of CML cells, and inhibits cancer progression in Myeloid leukemia via up-regulation of its target gene, 30/May/2017, 11.01 pm

Introduction: What they say: A study from the Department of Biochemistry-Molecular Biology, Franklin College of Arts and Sciences, The University of Georgia, Athens, Georgia 30602, USA; and The University of Georgia Cancer Center, The University of Georgia, Athens, Georgia 30602, USA shows that “Cancer progression by reprogrammed BCAA metabolism in myeloid leukaemia”. This study was […]

Swimming therapy for Stroke: Swimming training attenuates hippocampal neurons injury, augments regenerative neurogenesis after Ischemic Stroke, and ameliorates stroke damage and neurological deficits via up regulation of its target genes BDNF and NAMPT, 30/May/2017, 10.29 pm

Introduction: What they say A recent study from Research Center for Neurobiology and Department of Neurobiology, Xuzhou Medical College, 209 Tongshan Road, Xuzhou, Jiangsu 221004, PR China; and School of Public Health, Xuzhou Medical College, PR China shows that “HO-1 attenuates hippocampal neurons injury via the activation of BDNF-TrkB-PI3K/Akt signaling pathway in stroke.“ This study was published, in the July 2 […]