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November 16, 2017
Published by admin_auro at November 16, 2017
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Molecular therapy for Diabetic nephropathy (DN):  Epalrestat, an aldose reductase inhibitor used in the treatment of Diabetes Nephropathy, increases Pyruvate kinase M2 (PKM2) expression, decreases toxic glucose metabolites, mitochondrial dysfunction and apoptosis, augments glycolytic flux and PGC-1α levels, improves metabolic abnormalities, albuminuria, glomerular pathology, and renal dysfunction and alleviates diabetic nephropathy via down regulation of its target gene, 16/November/2017, 10.35 am

Introduction: What they say A study from the Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, USA shows that “Pyruvate kinase M2 activation may protect against the […]
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November 16, 2017
Published by admin_auro at November 16, 2017
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Lifespan extension therapy: 15-deoxy-Delta,12,14-prostaglandin J2 (15d-PGJ2) may increase life span via up-regulation of its target gene BubR1, 16/November/2017, 10.10 am

 What they say: Introduction:  A recent study from the Department of Genetics, Paul F. Glenn Laboratories for the Biological Mechanisms of Aging Harvard Medical School, Boston,USA; and […]
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November 16, 2017
Published by admin_auro at November 16, 2017
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Molecular therapy for glucose homeostasis and TIIDM: Butylphthalide (3-n-butylphthalide or NBP), found in celery oil,  increases Pax6 and insulin expression, decreases the levels of glucagon, ghrelin and Somatostatin, reduces metabolic stress, improves insulin sensitivity, promotes glucose homeostasis and prevents progression to TIIDM via down regulation of its target gene, 16/November/2017, 5.59 am

Introduction: What they say A study from the Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, […]
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November 16, 2017
Published by admin_auro at November 16, 2017
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Molecular therapy for Non-alcoholic fatty liver disease (NAFLD): Epalrestat, an aldose reductase inhibitor used in the treatment of Diabetic Neuropathy, promotes degradation of HMGCR, decreases the levels of triglycerides, free cholesterol, and total cholesterol and prevents the progression of Non-alcoholic fatty liver disease (NAFLD via down regulation of its target gene, 16/November/2017, 5.43 am

Significance of the study: Given that: (1)  15-30% of Western populations suffer from Non-alcoholic fatty liver disease (NAFLD), while 6-25% of Asian populations suffer from it; (2) 75 to […]
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