Anticancer therapy targeting the cancer stem cells: MiRNA-9600 decreases the expression of KLF4, suppresses proliferation, and promotes apoptosis of cancer cells via down regulation of its target gene, 24/January/2017, 10.49 pm
Research findings to Therapeutic opportunity: The study presented here suggests that MiRNA-9600, by increasing the expression of its target genes, it may decrease the expression of KLF4. [easy_payment currency=”USD”] Thereby, it may inhibit proliferation, and promote apoptosis of cancer cells. Thus, pharmacological formulations encompassing “MiRNA-9600 activators” may be used to inhibit cancer progression. Details of the research findings: Idea […]
Natural product-derived therapy for Metastatic human tumors: Gentian violet inhibits the expression of a number of enzymes in glycolytic cycle, and suppresses proliferation, migration, invasion, tumorigenesis and metastasis via up regulation of its target gene, 24/January/2017, 10.42 pm
Introduction: What they say: A study from the State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, Fujian 361102, China shows that “c-Src phosphorylation and activation of hexokinase promotes tumorigenesis and metastasis.” This study was published in the 5 January 2017 issue of the […]
Natural product-derived for brain repair and Lifespan extension: Curcumin increases VGF and BDNF expression, promotes Oligodendrocytes (OP) proliferation, triggers myelination on neurons, reverts neural damage, produces antidepressant like effects, and prolongs lifespan via up-regulation of its target gene, 23/January/2017, 11.59 pm
What they say: Introduction: A recent study from the Department of Biochemistry & Molecular Pharmacology, Smilow Research Center, Howard Hughes Medical Institute, NYU School of Medicine, 522 First Avenue, New York, NY 10016, USA shows that Running Triggers VGF-Mediated Oligodendrogenesis to Prolong the Lifespan of Snf2h-Null Ataxic Mice. This study was published in the 11 […]
Natural product-derived PD-1 pathway blockade for Human cancer therapy: Isoliquiritigenin, isolated from Licorice (Glycyrrhiza glabra), decreases the activity of Glycogen synthase kinase-3β, increases transcription factor T-bet expression, decreases the abundance of co-inhibitory receptor PD-1 on the cell surface of Cytotoxic-T-cells, increases cytotoxic T lymphocyte function and augments anti-tumor activity, via up-regulation of its target gene, 23/January/2017, 11.52 pm
Introduction:What they say: A recent study from Cell Signalling Section, Division of Immunology, Department of Pathology, Tennis Court Road, University of Cambridge, Cambridge CB2 1QP, UK shows that “Glycogen Synthase Kinase 3 Inactivation Drives T-bet-Mediated Downregulation of Co-receptor PD-1 to Enhance CD8(+) Cytolytic T Cell Responses.” This study was published in the 16 February 2016 issue […]
Immune enhancement therapy: Insulin increases SOX2 expression and promotes innate immunity against bacterial infection via down-regulation of its target gene, 23/January/2017, 11.38 pm
Introduction: What they say: A recent study from the Institute of Biophysics, Chinese Academy of Sciences, Beijing, China shows that “Sox2 functions as a sequence-specific DNA sensor in neutrophils to initiate innate immunity against microbial infection.” This study was published in the 2 March 2015 issue of the Journal “Nature Immunology” [the number one journal in immunological research with an impact factor of 24.973] by […]
MiRNA therapy for Regenerating the lost pancreatic β-cells in Diabetic patients: MiR-208a promotes an insulin-sensitized state via up-regulation of its target gene, 23/January/2017, 11.33 pm
Introduction: What they say: A study from the Stem Cell Transplantation Program, Division of Pediatric Hematology/Oncology, Boston Children’s Hospital and Dana-Farber Cancer Institute, Boston, Massachusetts, USA shows that “The Lin28/let-7 axis regulates glucose metabolism.” This study was published in the 30 September 2011 issue of the Journal “Cell” [One of the best journals in Biological sciences with an I.F of […]