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March 27, 2017

Natural product-derived PD-1 pathway blockade for Human cancer therapy: Methyl Jasmonate(MeJA), one of the main odour components of jasmine, decreases the activity of Glycogen synthase kinase-3β, increases transcription factor T-bet expression, decreases the abundance of co-inhibitory receptor PD-1 on the cell surface of Cytotoxic-T-cells, increases cytotoxic T lymphocyte function and augments anti-tumor activity, via up-regulation of its target gene, 27/March/2017, 11.24 pm

Introduction:What they say:  A recent study from Cell Signalling Section, Division of Immunology, Department of Pathology, Tennis Court Road, University of Cambridge, Cambridge CB2 1QP, UK […]
March 27, 2017

Natural product-derived therapy for Allergic rhinitis: Cucurbitacin E, found in Watermelons, inhibits GM-CSF, Interleukin 13 receptor(IL-13)-Rα1, and eotaxin expression, among others, inhibits mucus production and alleviates allergic rhinitis via up regulation of its target gene, 27/March/2017, 5.57 pm

What we say: Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-derived therapy for Allergic rhinitis: Cucurbitacin E, found in Watermelons,  inhibits GM-CSF, Interleukin 13 […]
March 27, 2017

Natural product-derived therapy for Human cancers: Linalool, one of the main components of Coriander leaves, increases the expression of mitochondrial protein LACTB, decreases levels of mitochondrial phosphatidylserine decarboxylase, alters mitochondrial lipid metabolism, and promotes differentiation of breast cancer cells via up-regulation of its target gene, 27/March/2017, 2.25 pm

Introduction: What they say: A study from the Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts, USA Department of Biology, Massachusetts Institute of Technology, […]
March 27, 2017

Natural product-based therapy for ageing-associated diseases: Berberine, found in Berberis, Berberis aristata, Hydrastis canadensis, Phellodendron amurense, and Argemone mexicana among others, increases NMN/NAD levels, decreases interaction of DBC1 with PARP1, increases PARP1 activity, promotes DNA repair, augments tolerance against radiation, cancer and aging via down regulation of its target gene, 27/March/2017, 1.54 pm

Introduction: What they say A study from Department of Genetics, Paul F. Glenn Center for the Biology of Aging, Harvard Medical School, Boston, MA, USA; and […]
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