Therapeutic insights into “awakening the sleeping/cancer-protecting angels” in mutant p53-expressing human tumors: Panax notoginseng saponins, isolated from Panax notoginseng (Burk), increases the expression of tumor suppressor p53 homologue TA-p73/p63, PTEN, TPM1, TIMP3, BTG2, PDCD4, SPRY1/2 and CCM1/KRIT1 and induces regression of p53-mutated human tumors via down regulation of its target gene, 1/January/2017, 11.23 am
From Significance of the study to Public health relevance: Given that: (1) Cancer suppressor p53 is mutated in more than 50% of human cancers of different tissue origin; (2) p53 pathway is altered in about 80% of tumors.; (3) our understanding is incomplete in terms of molecular targets and the oncogenic/malignant pathways involved in mutant […]
Molecular therapy for Human Leukemias: LRRC4/NGL-2 (Leucine rich repeat containing 4/Netrin-G ligand-2) suppresses B-Cell and myeloid leukemias via up regulation of the tumor suppressor IRF4, 31/December/2016, 12.16 pm
Introduction: What they say Noble laureate in Physiology/Medicine (1975) Prof. David Baltimore, from California Institute of Technology, California, USA, had reported in the July 8, 2014 issue of the Journal “Blood” that: “Dual mechanisms by which MiR-125b represses IRF4 to induce myeloid/B-cell leukemias.” What we say: On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Molecular therapy for Human Leukemias: LRRC4/NGL-2 […]
Natural product-derived regenerative therapy for improving muscle repair and strength in the elderly: γ-Bisabolene, found in Cardamom, cubeb, lemon and oregano, decreases the expression of HOXA9, increases skeletal muscle regeneration and improves muscle stem cells function and repair via up regulation of its target genes, 31/December/2016, 11.56 pm
Introduction: What they say A study from Faculty of Medicine, Friedrich-Schiller-University, Germany shows that “Epigenetic stress responses induce muscle stem-cell ageing by Hoxa9 developmental signals.” This research paper was published in the 30 November 2016 issue of the journal “Nature” [One of the best research journals in General Science with an I.F of 38+] by […]
Cardiac rejuvenation therapy: Secreted protein acidic and rich in cysteine (SPARC/osteonectin/BM-40) suppresses tumor suppressor INK4a/p16 expression, and inhibits dilated cardiomyopathy and heart failure via up regulation of its target gene, 31/December/2016, 11.25 am
Introduction: What they say A recent study from the Stem Cell Aging Group, Centro Nacional de Investigaciones Cardiovasculares, E-28029 Madrid, Spain shows that “Bmi1 limits dilated cardiomyopathy and heart failure by inhibiting cardiac senescence.” This study was published in the online journal 9 March 2015 issue of Nature Communications by Prof Gonzalez, Gonzalez-Valdes and others. […]
Natural product-derived therapy for Human Leukemias: Ginsenoside, one of components in American ginseng herb, found in stem of Caulis clematidis armandii and Hibiscus ficulneus, suppresses B-Cell and myeloid leukemias via up regulation of the tumor suppressor IRF4, 30/December/2016, 10.28 am
Introduction: What they say Noble laureate in Physiology/Medicine (1975) Prof. David Baltimore, from California Institute of Technology, California, USA, had reported in the July 8, 2014 issue of the Journal “Blood” that: “Dual mechanisms by which MiR-125b represses IRF4 to induce myeloid/B-cell leukemias.” What we say: On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-derived therapy for Human Leukemias: Ginsenoside, […]
Anti-telomerase cancer therapy: LRRC4/NGL-2 (Leucine rich repeat containing 4/Netrin-G ligand-2) suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and inhibits cancer progression via down-regulation of it target gene, 30/December/2016, 9.43 am
Introduction: What they say: The 1989 Nobel prize winner in Chemistry, Prof. Thomas R. Cech from the BioFrontiers Institute, USA has published a research paper in the 13 December 2012 issue of the Nature journal (492(7428):285-9; and I.F: >42) stating that “The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity.” This study provides mechanistic insights into how TPP1 regulates telomerase function. What we say: In connection with this finding, Dr Boominathan, Founder […]