Natural product Immune enhancement therapy: Fisetin, isolated from Strawberry, blueberries, mangoes, apples, persimmon, kiwi, onions, grapes and cucumber among others, increases SOX2 expression and promotes innate immunity against bacterial infection via down-regulation of its target gene, 14/December/2016, 8.57 am
Introduction: What they say: A recent study from the Institute of Biophysics, Chinese Academy of Sciences, Beijing, China shows that “Sox2 functions as a sequence-specific DNA sensor in neutrophils to initiate innate immunity against microbial infection.” This study was published in the 2 March 2015 issue of the Journal “Nature Immunology” [the number one journal in immunological research with an impact factor of 24.973] by Drs. […]
Therapeutic insights into “awakening the sleeping/cancer-protecting angels” in mutant p53-expressing human tumors: Kuwanon V, one of the constituents of Mulberry, increases the expression of tumor suppressor p53 homologue TA-p73/p63, PTEN, TPM1, TIMP3, BTG2, PDCD4, SPRY1/2 and CCM1/KRIT1 and induces regression of p53-mutated human tumors via down regulation of its target gene, 13/December/2016, 11.35 pm
From Significance of the study to Public health relevance: Given that: (1) Cancer suppressor p53 is mutated in more than 50% of human cancers of different tissue origin; (2) p53 pathway is altered in about 80% of tumors.; (3) our understanding is incomplete in terms of molecular targets and the oncogenic/malignant pathways involved in mutant […]
Natural product-derived Life-extension therapy: Cinnamaldehyde, one of the constituents of Cinnamon, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 13/December/2016, 11.16 pm
What they say? A recent study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.” This study was published in the 2 October 2009 issue of the Journal “Science” (I.F: 31.477 ) by Prof Dominic J. Withers, Dr. Selman C and others. What […]
Natural product-derived therapy for Human Leukemias: Grifolin, an antitumor natural product from mushroom Albatrellus confluens, suppresses B-Cell and myeloid leukemias via up regulation of the tumor suppressor IRF4, 13/December/2016, 11.01 pm
Introduction: What they say Noble laureate in Physiology/Medicine (1975) Prof. David Baltimore, from California Institute of Technology, California, USA, had reported in the July 8, 2014 issue of the Journal “Blood” that: “Dual mechanisms by which MiR-125b represses IRF4 to induce myeloid/B-cell leukemias.” What we say: On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-derived therapy for Human Leukemias: Grifolin, […]
Molecular therapy for Myocardial Infarction: Snail/SNAI1 (snail family zinc finger 1), a positive regulator of epithelial-mesenchymal transition, inhibits DNA damage responses, increases telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte survival after myocardial infarction via up-regulation of PNUTS, 13/December/2016, 10.42 pm
What they say: A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published in the 7 March 2013 issue of Nature by Prof Dimmler, Boon, and others. What we say: On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Molecular therapy for Myocardial Infarction: Snail/SNAI1 (snail family zinc finger 1), […]
Anticancer therapy: MiRNA-9600 increases the expression of pro-apoptotic protein RECK, inhibits proliferation, and promote apoptosis of cancer cells via down regulation of its target gene, 13/December/2016, 10.26 pm
Research findings to Therapeutic opportunity: The study presented here suggests that MiRNA-9600, by decreasing the expression of its target genes, it may increase the expression of pro-apoptotic protein RECK. [easy_payment currency=”USD”] Thereby, it may inhibit proliferation, and promote apoptosis of cancer cells. Thus, pharmacological formulations encompassing “MiRNA-9600 activators” may be used to inhibit cancer progression. Details of the research findings: […]