Natural product-based therapy for Cardiomyopathy: Methyl 3,5-dicaffeoyl quinate (MDQ), found in Salicornia herbacea L, and Aster Ohrai among others, induces the expression of Trbp/miR-208, restores the balance between slow- and fast-twitch myofiber proteins and alleviates Cardiomyopathy via up regulation of its target gene, 6/December/2016, 9.53 pm
Introduction: What they say: A study from the Department of Cardiology, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, USA; and Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, USA shows that “Trbp regulates heart function through microRNA-mediated Sox6 repression.“This study was published in the 2 June 2015 issue of the journal “Nature Genetics” (the number 1 research journal in […]
Natural product-based cardioprotective therapy: Theobromine, isolated from Theobroma and commonly found in chocolates, increases Spermidine levels, augments autophagy, mitophagy and mitochondrial respiration, lowers systemic blood pressure, and protects it from cardiac diseases via down regulation of its target gene, 6/November/2015, 9.39 pm
Introduction: What they say A study from the Institute of Molecular Biosciences, University of Graz, Humboldtstraße 50, A-8010 Graz shows that “Cardioprotection and lifespan extension by the natural polyamine spermidine.” This research paper was published in the 14 November 2016 issue of the journal “Nature Medicine” [One of the best research journals in General Biology […]
Molecular therapy for Myocardial Infarction: Amiodarone, a second line agent in the treatment of cardiac arrest, inhibits DNA damage responses, increases telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte survival after myocardial infarction via up-regulation of PNUTS, 6/December/2016, 3.20 pm
What they say: A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published in the 7 March 2013 issue of Nature by Prof Dimmler, Boon, and others. What we say: On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Molecular therapy for Myocardial Infarction: Amiodarone, a second line agent […]
MiRNA-based PD-1 pathway blockade for Human cancer therapy: MiR-940 decreases the expression of Glycogen synthase kinase-3β, increases transcription factor T-bet expression, decreases the abundance of co-inhibitory receptor PD-1 on the cell surface of Cytotoxic-T-cells, increases cytotoxic T lymphocyte function and augments anti-tumor activity, via up-regulation of its target gene, 6/December/2016, 12.46 pm
Introduction:What they say: A recent study from Cell Signalling Section, Division of Immunology, Department of Pathology, Tennis Court Road, University of Cambridge, Cambridge CB2 1QP, UK shows that “Glycogen Synthase Kinase 3 Inactivation Drives T-bet-Mediated Downregulation of Co-receptor PD-1 to Enhance CD8(+) Cytolytic T Cell Responses.” This study was published in the 16 February 2016 issue […]
Natural product-based Lifespan extension therapy: Apple extract increases the expression of longevity-promoting and antiaging gene Klotho via up regulation of its target gene, 5/December/2016, 11. 33 pm
What is known? It has been shown earlier that Klotho: (1) extends the lifespan of mice by about 19-31%; and (2) increases cognition. From Significance of the study to Therapeutic opportunity: This study suggests a natural product-based Life-extension therapy. Apple extract, by increasing the expression of its target genes, it may increase the expression of longevity-promoting and […]
Natural product-derived therapy for brain repair and Lifespan extension: Shikonin, found in Zicao (also known as purple gromwell), increases VGF and BDNF expression, promotes Oligodendrocytes (OP) proliferation, triggers myelination on neurons, reverts neural damage, produces antidepressant like effects, and prolongs lifespan via up-regulation of its target gene, 5/December/2016, 10.52 pm
What they say: Introduction: A recent study from the Department of Biochemistry & Molecular Pharmacology, Smilow Research Center, Howard Hughes Medical Institute, NYU School of Medicine, 522 First Avenue, New York, NY 10016, USA shows that Running Triggers VGF-Mediated Oligodendrogenesis to Prolong the Lifespan of Snf2h-Null Ataxic Mice. This study was published in the 11 […]