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February 20, 2017

Small molecule-based PD-L1 pathway blockade enhances the efficacy of Cancer immunotherapy: LRRC4/NGL2 (Leucine rich repeat containing 4/Netrin-G ligand-2) inhibits the expression of PD-L1, inhibits inflammatory signalling and the number of tumor-infiltrating lymphocytes and macrophages, increases Cytotoxic activity of T-cells, decreases tumor burden and increases survival via up-regulation of its target gene, 20/February/2017, 1.51 pm

Introduction:What they say: A recent study from Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Unit 108, 1515 Holcombe Boulevard, […]
February 20, 2017

Natural product-derived therapy for glucose homeostasis and TIIDM: Quercetin, found in Elderberry and Onions among others, increases Pax6 and insulin expression, decreases the levels of glucagon, ghrelin and Somatostatin, reduces metabolic stress, improves insulin sensitivity, promotes glucose homeostasis and prevents progression to TIIDM via down regulation of their target gene, 20/February/2017, 10.28 am

Introduction: What they say  A study from the Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, […]
February 20, 2017

Natural product-derived therapy for glucose homeostasis and TIIDM: Fucosterol, isolated from edible brown algae Ecklonia Cava/Stolonifera, inhibits Amysin expression, increases insulin secretion, and decreases the risk of hyperglycemia via down regulation of its target gene Sox4, 20/February/2017, 8.25 am

Introduction: What they say Nobel laureate in Physiology/Medicine (1975) Prof. David Baltimore and his research team, from California Institute of Technology, California, USA, had reported in […]
February 19, 2017

Small molecule-based PD-1 pathway blockade for Human cancer therapy: BMP2 (Bone Morphogenetic Protein-2) decreases the activity of Glycogen synthase kinase-3β, increases transcription factor T-bet expression, decreases the abundance of co-inhibitory receptor PD-1 on the cell surface of Cytotoxic-T-cells, increases cytotoxic T lymphocyte function and augments anti-tumor activity, via up-regulation of its target gene, 19/February/2017, 11.11 pm

Introduction:What they say:  A recent study from Cell Signalling Section, Division of Immunology, Department of Pathology, Tennis Court Road, University of Cambridge, Cambridge CB2 1QP, UK […]
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