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February 17, 2017

Natural product-derived PD-1 pathway blockade for Human cancer therapy: Apigenin (APG), a flavone commonly found in fruits and vegetables, decreases the activity of Glycogen synthase kinase-3β, increases transcription factor T-bet expression, decreases the abundance of co-inhibitory receptor PD-1 on the cell surface of Cytotoxic-T-cells, increases cytotoxic T lymphocyte function and augments anti-tumor activity, via up-regulation of its target gene, 17/February/2017, 11.59. pm

Introduction:What they say:  A recent study from Cell Signalling Section, Division of Immunology, Department of Pathology, Tennis Court Road, University of Cambridge, Cambridge CB2 1QP, UK […]
February 17, 2017

Natural product-based therapy for Metastatic cancers: (6)-gingerol (6G), one of the main components of Ginger, increases the expression of PDCD4 and inhibits migration, invasion and metastasis of cancer cells via down regulation of its target gene, 17/February/2017, 11.40 am,

Research findings to Therapeutic opportunity:  The study presented here suggests that (6)-gingerol (6G), by increasing the expression of its target genes, it may increase the expression of […]
February 17, 2017

Natural product-derived therapy for Human Leukemias: Linalool, one of the main components of Coriander and Lamiaceae among others, suppresses B-Cell and myeloid leukemias via up regulation of the tumor suppressor IRF4, 17/February/2017, 11.12 pm

Introduction: What they say Noble laureate in Physiology/Medicine (1975) Prof. David Baltimore, from California Institute of Technology, California, USA, had reported in the July 8, 2014 issue of the Journal “Blood” that: “Dual mechanisms […]
February 17, 2017

Anti-telomerase cancer therapy: CGI-58/ABHD5 (Comparative gene identification-58/α/β-hydrolase domain-containing 5) suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and the cellular immortality gene telomerase and inhibits cancer progression via down-regulation of it target gene, 17/February/2017, 10.48 pm

Introduction: What they say:   The 1989 Nobel prize winner in Chemistry, Prof. Thomas R. Cech from the BioFrontiers Institute, USA has published a research paper in the 13 December 2012 issue of the Nature journal (492(7428):285-9; and I.F: >42) stating that “The TEL […]
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