Natural product therapy for brain repair and Life-span extension: Ursolic acid, found in Tulsi and apple peels, among others, increases VGF and BDNF expression, promotes Oligodendrocytes (OP) proliferation, triggers myelination on neurons, reverts neural damage, produces anti-depressant like effects, and prolongs lifespan via up-regulation of its target gene, 28/October/2016, 9.29 pm
What they say: Introduction: A recent study from the Department of Biochemistry & Molecular Pharmacology, Smilow Research Center, Howard Hughes Medical Institute, NYU School of Medicine, 522 First Avenue, New York, NY 10016, USA shows that “Voluntary Running Triggers VGF-Mediated Oligodendrogenesis to Prolong the Lifespan of Snf2h-Null Ataxic Mice.” This study was published in […]
Natural product Lifespan extension therapy: Thermostable extract of fenugreek seeds increases life span via up-regulation of its target gene BubR1, 28/October/2016, 3.04 pm
What they say: Introduction: A recent study from the Department of Genetics, Paul F. Glenn Laboratories for the Biological Mechanisms of Aging Harvard Medical School, Boston,USA; and Department of Pharmacology, School of Medicine, The University of New South Wales, Australia shows that Sirtuin-2 induces the checkpoint kinase BubR1 to increase lifespan. This study was published in the 1 July 2014 issue of the journal “EMBO” by Prof […]
Natural product therapy for tuberculosis: α-Lipoic acid, found in broccoli, yams, tomatoes, Brussels sprouts, carrots, and rice bran, among others, increases the expression of MKP-1, inhibits TLR2 signalling, secretion of Chemokine CXCL5, and recruitment of polymorphonuclear leukocytes (PMNs), decreases destructive pulmonary inflammation, promotes M. tuberculosis clearance and inhibits pulmonary tuberculosis via up-regulation of its target gene, 28/October/2016, 2.46 pm
Introduction: A study from the Max Plank Institute for Infection Biology, Berlin, Germany shows that “CXCL5-secreting pulmonary epithelial cells drive destructive neutrophilic inflammation in tuberculosis.” This study was published in the 10 February 2014 issue of the“Journal of Clinical Investigation” [One of the best research journals in clinical medicine with an impact factor of 12.575] […]
Natural product therapy for Myocardial Infarction: Ampelopsin (AMP), a flavnol mainly found in Ampelopsis grossedentata (commonly known as Mayeam), improves myocardial function after myocardial infarction via up regulation of PNUTS/PPP1R10 (Serine/threonine-protein phosphatase 1 regulatory subunit 10), 28/October/2016, 10.29 am
Introduction: A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published in the 7 March 2013 issue of Nature by Prof Dimmler, Boon, and others. On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product therapy for Myocardial Infarction: Ampelopsin (AMP), a flavnol mainly found in Ampelopsis grossedentata (commonly […]
Anti-telomerase cancer therapy: Bisindole-PBD (Compound 5b) suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and inhibits cancer progression via down-regulation of its target gene, 28/October/2016, 9.00 am
Introduction: The 1989 Nobel prize winner in Chemistry, Prof. Thomas R. Cech from the BioFrontiers Institute, USA has published a research paper in the 13 December 2012 Nature (492(7428):285-9; and I.F: >42) stating that “The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity.” This study provides mechanistic insights into how TPP1 regulates telomerase function. In connection with this finding, Dr Boominathan, Founder Director-cum-chief scientist of GBMD, reports that: Anti-telomerase cancer therapy: Bisindole-PBD (Compound 5b) suppresses the expression […]
Molecular therapy for Regenerating the lost pancreatic β-cells in Diabetic patients: NURR1 promotes an insulin-sensitized state via up-regulation of reprogramming protein Lin28, 28/October/2016, 8.18 am
Introduction: A study from the Stem Cell Transplantation Program, Division of Pediatric Hematology/Oncology, Boston Children’s Hospital and Dana-Farber Cancer Institute, Boston, Massachusetts, USA shows that “The Lin28/let-7 axis regulates glucose metabolism.” This study was published in the 30 September 2011 issue of the Journal “Cell” [One of the best journals in Biological sciences with an I.F of 28.71] by Prof Daley GQ, […]