Natural product Lifespan extension therapy: Isorhapontigenin, isolated from Aiphanes Aculeata, Norway/Sitka/white Spruce, among others, increases life span via up-regulation of its target gene BubR1, 26/October/2016, 3.18 pm
What they say: Introduction: A recent study from the Department of Genetics, Paul F. Glenn Laboratories for the Biological Mechanisms of Aging Harvard Medical School, Boston,USA; and Department of Pharmacology, School of Medicine, The University of New South Wales, Australia shows that Sirtuin-2 induces the checkpoint kinase BubR1 to increase lifespan. This study was published in the 1 July 2014 issue of the journal “EMBO” by Prof […]
Natural product therapy for brain repair and Life-span extension: Resveratrol, an activator of longevity promoting gene Sirtuin-1, increases VGF and BDNF expression, promotes Oligodendrocytes (OP) proliferation, triggers myelination on neurons, reverts neural damage, produces anti-depressant like effects, and prolongs lifespan via up-regulation of its target gene, 26/October/2016, 7.10 am
What they say: Introduction: A recent study from the Department of Biochemistry & Molecular Pharmacology, Smilow Research Center, Howard Hughes Medical Institute, NYU School of Medicine, 522 First Avenue, New York, NY 10016, USA shows that “Voluntary Running Triggers VGF-Mediated Oligodendrogenesis to Prolong the Lifespan of Snf2h-Null Ataxic Mice.” This study was published in […]
Natural product therapy targeting aberrant Lipid synthesis in Human cancers: Thymoquinone, isolated from Monarda Fistulosa, suppresses the expression of the principal enzyme in lipid synthesis, ACLY, inhibits aberrant lipid production, and tumor progression via up-regulation of its target gene, 26/October/2016, 6.00 am
A recent study from Rutgers Cancer Institute of New Jersey, Rutgers University, The State University of New Jersey, New Brunswick, New Jersey, USA shows that “Cullin3–KLHL25 ubiquitin ligase targets ACLY for degradation to inhibit lipid synthesis and tumor progression.” This study was published in the 1 September 2016 issue of Genes Development by Prof Feng Z, Zhang C, and others. On the foundation of this […]
Natural product Lifespan extension therapy: Green tea extract increases life span via up-regulation of its target gene BubR1, 25/October/2016, 9.01 am
A recent study from the Department of Genetics, Paul F. Glenn Laboratories for the Biological Mechanisms of Aging Harvard Medical School, Boston,USA; and Department of Pharmacology, School of Medicine, The University of New South Wales, Australia shows that Sirtuin-2 induces the checkpoint kinase BubR1 to increase lifespan. This study was published in the 1 July 2014 issue of the journal “EMBO” by Prof Sinclair, North BJ, and others. […]
Molecular therapy for Myocardial dysfunction: MiR-26 increases CDK inhibitor p27 expression, inhibits mTOR pathway, promotes autophagy in myocardial cells and prevents myocardial dysfunction via down-regulation of its target gene, 25/October/2016, 8.50 am
Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports here that: Molecular therapy for Myocardial dysfunction: MiR-26 increases CDK inhibitor p27 expression, inhibits mTOR pathway, promotes autophagy in myocardial cells and prevents myocardial dysfunction via down-regulation of its target gene Significance: Given that: (1) cardiovascular disease is the leading cause of death worldwide; (2) in India, in 2004, […]
Natural product therapy for Diabetes mellitus: Sulforaphane, found in Brussels Sprouts, Broccoli, Cabbage, Cauliflower, Kale, among others, increases islet insulin levels, islet cell mass and glucose tolerance via down-regulation of NMDA receptor GluN2A, 25/October/2016, 8.34 am
A study from the Institute of Metabolic Physiology, Heinrich Heine University, Düsseldorf, Germany shows that: “Characterization of pancreatic NMDA receptors as possible drug targets for diabetes treatment.” This study was published in the 16 March 2015 issue of the Journal “Nature Medicine” (one of the best journal in “General Medicine” with an impact factor of 28) by Prof. Lammert E, Marquard J and […]