Natural product Life-extension therapy: Saponin D, an active component isolated from Pulsatilla koreana, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 27/September/2016, 9.51 pm

A recent study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.” This study was published in the 2 October 2009 issue of the Journal “Science” (I.F: 31.477 ) by Prof Dominic J. Withers, Dr. Selman C and others. On the foundation of […]

Natural product Life-span extension therapy: Carnosic acid (CA), isolated from Rosemary (Rosemarinus officinalis), increases life span by suppressing mTOR pathway through up regulation of its target gene, 27/September/2016, 9.33 pm

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Web: http://genomediscovery.org or http://newbioideas.com Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/  Significance:   This study suggests, for the first time, that Carnosic acid, isolated from Rosemary, by suppressing the expression of mTOR, it may: (i) increase autophagic flux; (ii) decrease reactive oxygen species; and (iii) increase  the lifespan of an individual. Of interest, decreasing the expression/activity of mTOR […]

Natural product therapy for Myocardial Infarction: (+)-Syringaresinol, isolated from Panax ginseng berry, improves myocardial function after myocardial infarction via up regulation of PNUTS/PPP1R10 (Serine/threonine-protein phosphatase 1 regulatory subunit 10), 26/September/2016, 10.54 pm

A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published in the 7 March  2013 issue of Nature  by Prof Dimmler, Boon, and others. On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product therapy for Myocardial Infarction: (+)-Syringaresinol, isolated from Panax ginseng berry, improves myocardial function […]

Anti-telomerase cancer therapy: miR-204 suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and inhibits cancer progression via down regulation of its target gene, 26/September/2016, 10.29 pm

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Undisclosed information: How MIR-204 suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ The 1989 Nobel prize winner in Chemistry, Prof. Thomas R. Cech from the BioFrontiers Institute, USA has published a research paper in the 13 December 2012 Nature (492(7428):285-9; and I.F: >42) stating that “The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity.”  This study provides mechanistic insights into how TPP1 regulates telomerase function. In […]

Natural product Life-span extension therapy: Thermostable extract of fenugreek seeds increases life span by suppressing mTOR pathway through up regulation of its target gene, 26/September/2016, 10.10 pm

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Web: http://genomediscovery.org or http://newbioideas.com Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/  Significance:   This study suggests, for the first time, that  Thermostable extract of fenugreek seeds, by increasing the expression of its target gene, it may suppress the expression of mTOR. Thereby, it may: (i) increase autophagic flux; (ii) decrease reactive oxygen species; and (iii) increase  the […]

Natural product therapy for pulmonary arterial hypertension: Scutellaria baicalensis inhibits the development of pulmonary arterial hypertension via down regulation of its target gene Notch3, 26/September/2016, 9.54 pm

A study from the University of California, La Jolla, California, USA shows that “Notch3 signaling promotes the development of pulmonary arterial hypertension.” This study was published in the 15 November  2009 issue of the journal “Nature Medicine”[the number 1 journal in General Medicine with an I.F of 28.054] by Prof. Thistlethwaite PA, Li X and others. On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product therapy for pulmonary arterial hypertension: Scutellaria baicalensis inhibits the […]