Life-span extension therapy: Endothelin-1 inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span via up regulation of its target gene, 13/June/2015, 10.50 am

A recent study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.” This study was published in the 2 October 2009 issue of the Journal “Science” (The number 2 journal in General science with an I.F of […]

Natural product-based Regenerative Stem cell therapy for Myocardial Infarction: Kaempherol improves myocardial function after myocardial infarction via up regulation of PNUTS/PPP1R10 (Serine/threonine-protein phosphatase 1 regulatory subunit 10), 13/June/2015, 7.07 am

A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published in the 7 March  2013 issue of Nature  by Prof Dimmler, Boon, and others. On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product–based Regenerative Stem cell therapy for Myocardial Infarction: Kaempherol improves myocardial function after myocardial infarction via up regulation […]

Natural product-based therapy for leukaemia: Cirsilol (3′,4′,5-trihydroxy-6,7-dimethoxyflavone), a flavone isolated from Achillea fragrantissima, suppresess B-cell lineage acute lymphoid leukaemia via up regulation of its target gene, 12/June/2015, 11.13 pm

A recent study from the Department of Laboratory Medicine, University of California San Francisco, San Francisco, California 94143, USA;  and Department of Haematology, University of Cambridge, Cambridge CB2 OAH, UK” shows that Identification of FOXM1 as a therapeutic target in B-cell lineage acute lymphoid leukaemia. This study was published in the 10 March  2015 issue of the Online journal “Nature Communication”  by Prof Müschen […]

MiRNA-based Anti-virus therapy: MiRNA-214 suppresses dengue virus replication via up regulation of its target gene, 12/June/2015, 11.00 pm

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, L., MiRNA-based Anti-virus therapy: MiRNA-214 suppresses dengue virus replication via up regulation of its target gene, 12/June/2015, 11.00 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Significance:  This suggests, for the first time, that MiRNA-214, by decreasing the expression of its target gene, it may suppress dengue virus replication.  Thus, pharmacological formulations encompassing “MiRNA-214 or its activators“ may be […]

Natural product-based therapy for metastatic breast cancer: I3C, a natural compound found in Broccoli & Brussels, blocks bone metastasis of mammary cancer via down regulation of its target gene, 12/June/2015, 10.51 pm

A study from the Biotech Research and Innovation Centre, University of Copenhagen, Copenhagen, Denmark; and Hypoxia and Metastasis Team, Cancer Research UK Tumour Cell Signalling Unit, The Institute of Cancer Research, London SW3 6JB, UK shows that “The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase.” This study was published in the 27 May 2015 issue of the journal “Nature” [the number […]

Rescuing the cerebral ischemia-mediated brain damage: MiRNA-107 attenuates cerebral ischemia-mediated brain damage via down regulation of its target gene, 12/June/2015, 9.48 pm

A recent study from the Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria, Peoria, IL, USA shows that “Post-transcriptional inactivation of matrix metalloproteinase-12 after focal cerebral ischemia attenuates brain damage.” This study was published in the 8 May 2015 issue of the Journal “Sci Reports” by Prof Veeravalli KK, Chelluboina B and Others. On the foundation of this interesting finding, Dr L Boominathan […]