Molecular therapy for NIDDM: Lin28 inhibits gluconeogenesis and hyperglycemia via up regulation of Cyclin D1, 10/June/2015, 6.55 am
A study from the Department of Cancer Biology, Dana-Farber Cancer Institute; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA; and others shows that “Cyclin D1–Cdk4 controls glucose metabolism independently of cell cycle progression.” This study was published in the June 26, 2014 issue of Nature [the number 1 journal in General science with an I.F of >42] by Prof. Puigserver and others from the Department of Cancer Biology, […]
Natural product-based therapy for Myopathy: Berberine, an isoquinoline derivative alkaloid isolated from medicinal herbs, induces autophagy, maintains blood sugar during fasting, decreases aging-associated myopathy and mitochondrial dysfunction via up regulation of its target gene, 10/June/2015, 12.05 pm
A recent study from the Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, Main Street West, Hamilton, Canada; Department of Biochemistry and Biomedical Sciences, McMaster University, 1280 Main Street West, Hamilton, ON L8N 3Z5, Canada shows that “AMPK Activation of Muscle Autophagy Prevents Fasting-Induced Hypoglycemia and Myopathy during Aging“ This study was published in the 2 […]
Small molecule-based Regenerative Stem cell therapy for Myocardial Infarction: Ursodeoxycholic acid (UDCA) improves myocardial function after myocardial infarction via up regulation of PNUTS/PPP1R10 (Serine/threonine-protein phosphatase 1 regulatory subunit 10), 9/June/2015, 11.16 pm
A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published in the 7 March 2013 issue of Nature by Prof Dimmler, Boon, and others. On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Small molecule-based Regenerative Stem cell therapy for Myocardial Infarction: Ursodeoxycholic acid (UDCA) improves myocardial function after myocardial infarction via up […]
Mechanistic insight into ageing: Advanced glycation end products (AGEs) increase the expression of tumor suppressor p53 and ageing features via down regulation of their target gene, 9/June/2015, 9.15 pm
Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, Mechanistic insight into ageing: Advanced glycation end products (AGEs) increase the expression of tumor suppressor p53 and ageing features via down regulation of their target gene, 9/June/2015, 9.15 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Significance: It has been shown earlier that Advanced glycation end products (AGEs) increase the generation of reactive […]
Natural product-based therapy for renal and retinal complications in Diabetes: Ursolic acid, enriched in apple peels and Tulsi, protects against renal and retinal injury in diabetes via up regulation of its target gene, 9/June/2015, 7.03 pm
Significance: Given that (1) more than 387 million people worldwide are affected by Diabetes mellitus (DM); (2) the life-long painful injection/drug treatment required to treat DM; (3) DM is often associated with a number of other diseases such as diabetic nephropathy, diabetic cardiomyopathy, diabetic retinopathy, hypertension, myocardial infarction, cardiac hypertrophy etc; and (4) the global economic cost […]
Natural product-based therapy for Hypertension: Eugenol, a natural compound isolated from herb Ocimum sanctum Linn (Tulsi), relaxes vascular smooth muscle cells, and decreases blood pressure by increasing the expression of SERCA and BKCa Channels, 9/June/2015, 2.50 pm
A study from the Walter-Brendel Centre of Experimental Medicine and Biomedical Center and Walther Straub Institute, Pharmacology, Ludwig-Maximilians Universität München, Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany; DZHK (German Center for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany; Division of Cell Signalling and Immunology, University of Dundee, Scotland, United Kingdom; Institute […]