Molecular therapy for Human Cancer: HGF suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) via up regulation of its target gene, 20/May/2014, 23.49

The 1989 Nobel prize winner in Chemistry, Prof. Thomas R. Cech from the BioFrontiers Institute, USA has published a research paper in the 13 December 2012 Nature (492(7428):285-9; and I.F: >42) stating that “The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity.”  This study provides mechanistic insights into how TPP1 regulates telomerase function. In connection with this finding, Dr Boominathan, Founder Director-cum-chief scientist of GBMD, reports that: Molecular therapy for Human Cancer: HGF suppresses the expression of […]

MiRNA-based Diabetes mellitus therapy: MiRNA-130 increases human pancreatic beta cell replication via down regulation of its target gene DYRK1A, 20/May/2015, 23.35

A study from the Diabetes, Obesity and Metabolism Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA and Division of Endocrinology and Bone Disease, Icahn School of Medicine at Mount Sinai, New York, New York, USA  shows that “A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replication.” This […]

Small molecule-based therapy for pulmonary arterial hypertension: Leucine, an essential amino acid, inhibits the development of pulmonary arterial hypertension via down regulation of its target gene Notch3, 20/May/2015, 23.32

A study from the University of California, La Jolla, California, USA shows that “Notch3 signaling promotes the development of pulmonary arterial hypertension.” This study was published in the 15 November  2009 issue of the journal “Nature Medicine”[the number 1 journal in General Medicine with an I.F of 28.054] by Prof. Thistlethwaite PA, Li X and others. On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Small molecule-based therapy for pulmonary arterial hypertension: Leucine, an essential […]

Small RNAs can make you taller: MiRNA-130 increases the expression of Growth hormone (GH) via down regulation of its target gene, 20/May/2015, 23.29

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, L., Small RNAs can make you taller: MiRNA-130 increases the expression of Growth hormone (GH) via down regulation of its target gene, 20/May/2015, 23.29, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Significance:  This suggests, for the first time, that MiRNA-130, by decreasing the expression of its target gene, it may increase the expression of Growth hormone […]

Natural product-based Lifespan extension therapy: Natural product Cucurbitacin I (JSI-124) inhibits senescence and extends life span by down regulating the expression of adenylate cyclase 5 (ADCY5), 20/May/2015, 23.27

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, L., Natural product-based Lifespan extension therapy: Natural product Cucurbitacin I (JSI-124) inhibits senescence and extends life span by down regulating the expression of  adenylate cyclase 5 (ADCY5), 20/May/2015, 23.27, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Web: http://genomediscovery.org Courtesy: When you cite drop us a line at info@genomediscovery.org * Research cooperation Significance:  This study suggests, for the first […]

Natural product-based therapy for DM: Ursolic acid, enriched in apple peels and Tulsi, lowers hepatic glucose production and plasma glucose levels via up regulation of its target gene, 20/May/2015, 23.16

A recent study from the [1] Toronto General Research Institute and Department of Medicine, Toronto, Ontario, Canada, [2] Department of Physiology, University of Toronto, Toronto, Ontario, Canada, [3] Department of Medicine, University of Toronto, Toronto, Ontario, Canada, and [4] Banting and Best Diabetes Centre, University of Toronto, Toronto, Ontario, Canada shows that “Metformin activates a duodenal Ampk-dependent pathway […]