Anticancer stem cell therapy: Gremlin-1 suppresses the expression of tumor suppessor PTEN via down regulation of its target gene, 18/May/2015, 22.20
A recent study from the Gastrointestinal Stem Cell Biology Laboratory, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK; Translational Gastroenterology Unit, Experimental Medicine Division,, shows that Aberrant epithelial Gremlin-1 expression initiates colonic tumorigenesis from cells outside the stem cell niche. This study was published in the 1 December 2014 issue of the Journal “Nature Medicine” [the number 1 journal in General […]
Natural product-based therapy for pulmonary arterial hypertension: Phlorotannin, isolated from the edible brown alga Ecklonia stolonifera, inhibits the development of pulmonary arterial hypertension via down regulation of its target gene Notch3, 18/May/2015, 22.15
A study from the University of California, La Jolla, California, USA shows that “Notch3 signaling promotes the development of pulmonary arterial hypertension.” This study was published in the 15 November 2009 issue of the journal “Nature Medicine”[the number 1 journal in General Medicine with an I.F of 28.054] by Prof. Thistlethwaite PA, Li X and others. On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-based therapy for pulmonary arterial hypertension: Phlorotannin, isolated […]
MiRNA-based Diabetes mellitus therapy: MiRNA-540 increases human pancreatic beta cell replication via down regulation of its target gene DYRK1A, 18/April/2015, 22.08
A study from the Diabetes, Obesity and Metabolism Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA and Division of Endocrinology and Bone Disease, Icahn School of Medicine at Mount Sinai, New York, New York, USA shows that “A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replication.” This […]
Small molecule-based Lifespan extension therapy: COP1 extends mammalian life span via up regulation of its target gene BubR1, 18/May/2015, 22.04
A recent study from the Department of Genetics, Paul F. Glenn Laboratories for the Biological Mechanisms of Aging Harvard Medical School, Boston,USA; and Department of Pharmacology, School of Medicine, The University of New South Wales, Australia shows that Sirtuin-2 induces the checkpoint kinase BubR1 to increase lifespan. This study was published in the 1 July 2014 issue of the journal “EMBO” by Prof David Andrew Sinclair, North […]
MiRNA-based therapy for Human Cancer: MiRNA-320 suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) via up regulation of its target gene, 18/May/2015, 21.55
The 1989 Noble prize winner in Chemistry, Prof. Thomas R. Cech, from the University of Colorado BioFrontiers Institute, USA, has published a research paper in the 13 December 2012 Nature (492(7428):285-9; and I.F: >42) stating that “The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity.” This study provides mechanistic insights into how TPP1 regulates telomerase function. In connection with this finding, Dr Boominathan, Founder Director-cum-chief scientist […]
Natural product-based Life extension therapy: Berberine increases catalase expression, decreases oxidative damage and promotes longevity via up regulation of its target gene, 18/May/2015, 12.51 pm
A recent study from the Department of Genome Sciences, University of Washington, Seattle, USA shows that “Extension of murine life span by overexpression of catalase targeted to mitochondria.” This study was published in the 24 June 2015 issue of the journal “Science” [the number 2 journal in General Science with an I.F of 31.477] by Prof Rabinovitch PS, Schriner and others. On the foundation of this interesting […]