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December 19, 2016
Published by admin_auro at December 19, 2016
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Immune enhancement therapy: HIF-2α increases SOX2 expression and promotes innate immunity against bacterial infection via down-regulation of its target gene, 19/December/2016, 10.14 pm

Introduction: What they say:  A recent study from the Institute of Biophysics, Chinese Academy of Sciences, Beijing, China shows that “Sox2 functions as a sequence-specific DNA sensor in neutrophils […]
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December 19, 2016
Published by admin_auro at December 19, 2016
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Therapeutic insights into “awakening the sleeping/cancer-protecting angel” in mutant p53-expressing human tumors: MiR-329 increases the expression of tumor suppressor p53 homologue TAp73 and induces regression of p53-mutated human tumors via down regulation of its target gene, 19/December/2016, 10.04 pm

From Significance of the study to Public health relevance: Given that: (1) Cancer suppressor p53 is mutated in more than 50% of human cancers of different […]
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December 19, 2016
Published by admin_auro at December 19, 2016
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Molecular therapy for triple-negative breast tumors: PDLIM2 increases the levels of cell cycle inhibitor, p27, inhibits pro-survival pathways mediated by c-Myc, and inhibits the progression of triple-negative breast cancer via up-regulation of its target gene, 19/December/2016, 9.56 pm

Introduction: What they say A study from the Department of Cell and Tissue Biology, University of California, San Francisco (UCSF), San Francisco, California, USA shows that […]
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December 19, 2016
Published by admin_auro at December 19, 2016
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Small molecule-based PD-1 pathway blockade for Human cancer therapy: UBTD1 (Ubiquitin domain containing 1) inhibits the expression of co-inhibitory receptor PD-1 on Antigen- Specific T-cells, increases the production of cytokines by tumor-infiltrating lymphocytes (TIL), and draining lymph nodes and augments anti-tumor activity via down-regulation of its target gene, 19/December/2016, 9.49 pm

Introduction:What they say: A recent study from Division of Infectious Diseases, School of Medicine, Johns Hopkins University, Baltimore, MD 21218, United States shows that “TGF-β1-Mediated Smad3 […]
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