Ethyl pyruvate-based therapy for diabetes: Ethyl pyruvate decreases DNA-PPK expression, suppresses phosphorylation of HSP90a, increases AMPK activity, augments mitochondrial biogenesis and energy metabolism, promotes weight loss and exercise endurance and alleviates TIIDM, via down-regulation of its target gene, 22/March/2019, 8.55 am
Introduction: What they say A study from the Laboratory of Obesity and Aging Research, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA; and Laboratory of Obesity and Aging Research, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA shows that “DNA-PK Promotes the Mitochondrial, […]
A gaseous way to keep cardiac diseases at bay: Hydrogen gas-based cardiac rejuvenation therapy: Inhalation or Subcutaneous injection of hydrogen gas suppresses tumor suppressor INK4a/p16 expression, and inhibits dilated cardiomyopathy, via up regulation of its target gene, 22/March/2019, 8.40 am
What we say: Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: A gaseous way to keep cardiac diseases at bay: Hydrogen gas-based cardiac rejuvenation therapy: Inhalation or Subcutaneous injection of hydrogen gas suppresses tumor suppressor INK4a/p16 expression, and inhibits dilated cardiomyopathy, via up regulation of its target gene From the Significance of the study […]
Ribonucleic acid-based therapy for Diabetes Mellitus: LncRNA LINC00319 augments the expression of FGF19 and FGF1, attenuates hepatic glucose production, decreases hepatic acetyl CoA content, brings down the levels of plasma ACTH, and corticosterone, augments insulin sensitivity, promotes weight loss and alleviates TIDM, via upregulation of its target gene, 22/March/2019, 8.23 am
Introduction: What they say A study from Diabetes and Obesity Center of Excellence, Department of Medicine, University of Washington, Seattle, Washington, USA shows that Central injection of FGF1 induces sustained remission of diabetic hyperglycemia in rodents. This research paper was published, in the 23 May 2016 issue of the journal “Nature Medicine” [One of the […]
Ribonucleic acid-based therapy for autoimmune diabetes (TIDM): LncRNA H19 increases PD-L1 expression, increases Tregs function, promotes immune tolerance, increases pancreatic β-cell proliferation and regeneration, increases insulin secretion, improves insulin sensitivity, increases energy utilization, and reverses TIDM, via up regulation of its target gene, 22/March/2019, 8.14 am
Introduction: What they say A study from the International Center for T1D, Pediatric Clinical Research Center Romeo ed Enrica Invernizzi, “L. Sacco” Department of Biomedical and Clinical Sciences, University of Milan, Milan 20157, Italy; and Nephrology Division, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02115, USA shows that “PD-L1 genetic overexpression or pharmacological restoration in […]
Ribonucleic acid-based therapy for glaucoma: LncRNA PVT1 increases Nmnat1 expression, increases NAD+ levels, improves neuronal dysfunction, and protects against glaucoma, via down regulation of its target gene, 22/March/2019, 8.05 am
Introduction: What they say A study from the The Jackson Laboratory, Bar Harbor, ME 04609, USA; Department of Ophthalmology, Tufts University of Medicine, Boston, MA 02111, USA; The Howard Hughes Medical Institute, Bar Harbor, ME 04609, USA shows that “Vitamin B3 modulates mitochondrial vulnerability and prevents glaucoma in aged mice.” This research paper was published, […]
Hydrogen gas-based therapy for attenuating pathogenesis-associated with Myocardial infarction: Subcutaneous injection or inhalation of hydrogen gas decreases IRF3, GM-CSF (Granulocyte-macrophage colony-stimulating factor) and GRK2(G protein-coupled receptor kinase) expression, inhibits undue leukocyte activation and invasion, suppresses recruitment of inflammatory cells, inhibits ventricular dilation, and promotes heart repair and survival, via up regulation of its target gene, 21/March/2019, 7.45 pm
Introduction: What they say: A recent study from Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, USA; and Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA shows that “IRF3 and type I interferons fuel a fatal response to myocardial infarction.” This study was published, in the 6 November 2017 […]