Stalling metastatic cancer spread by exposing it to the Sunlight: Calcitriol (1α, 25-dihydroxyvitamin D3) increases the expression of tumor suppressor RECK and inhibits migration and invasion of metastatic cancer cells via down regulation of its target gene, 24/April/2015, 12.20 pm
Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Significance: This study suggests a vitamin-based Anti-metastasis therapy. 1α, 25-dihydroxyvitamin D3 (Calcitriol), by increasing the expression of its target genes, it may increase the expression of tumor suppressor RECK. Thereby, it may inhibit migration and invasion of metastatic cancer cells. Thus, pharmacological formulations encompassing ” Calcitriol or its analogues” may be […]
Natural product-based therapy for pulmonary arterial hypertension: Cinnamaldehyde (CA) inhibits the development of pulmonary arterial hypertension via down regulation of its target gene Notch3, 24/April/2015, 7.59 am
A study from the University of California, La Jolla, California, USA shows that “Notch3 signaling promotes the development of pulmonary arterial hypertension.” This study was published in the 15 November 2009 issue of the journal “Nature Medicine”[the number 1 journal in General Medicine with an I.F of 28.054] by Prof. Thistlethwaite PA, Li X and others. On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-based therapy for pulmonary arterial hypertension: Cinnamaldehyde (CA) inhibits […]
Molecular therapy for Human Cancer: GATA3 suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) via up regulation of its target gene, 24/April/2015, 7.54 am
The 1989 Noble prize winner in Chemistry, Prof. Thomas R. Cech, from the University of Colorado BioFrontiers Institute, USA, has published a research paper in the 13 December 2012 Nature (492(7428):285-9; and I.F: >42) stating that “The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity.” This study provides mechanistic insights into how TPP1 regulates telomerase function. In connection with this finding, Dr Boominathan, Founder Director-cum-chief scientist […]
Regenerating the lost cardiomyocytes in myocardial patients: Unacylated ghrelin (UnAG) improves myocardial function after myocardial infarction via up regulation of PNUTS/PPP1R10 (Serine/threonine-protein phosphatase 1 regulatory subunit 10), 24/April/2014, 7.47 am
A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published in the 7 March 2013 issue of Nature by Prof Dimmler, Boon, and others. On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Regenerating the lost cardiomyocytes in myocardial patients: Unacylated ghrelin (UnAG) improves myocardial function after myocardial infarction via up […]
Natural product-based Regenerative therapy for Diabetes mellitus: Yellow Capsicum extract increases human pancreatic beta cell replication via down regulation of its target gene DYRK1A, 24/April/2015, 12.43 am
A study from the Diabetes, Obesity and Metabolism Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA and Division of Endocrinology and Bone Disease, Icahn School of Medicine at Mount Sinai, New York, New York, USA shows that “A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replication.” This […]
Natural product-based therapy for pulmonary arterial hypertension: Rubi Fructus inhibits the development of pulmonary arterial hypertension via down regulation of its target gene Notch3, 24/April/2015, 12.39 am
A study from the University of California, La Jolla, California, USA shows that “Notch3 signaling promotes the development of pulmonary arterial hypertension.” This study was published in the 15 November 2009 issue of the journal “Nature Medicine”[the number 1 journal in General Medicine with an I.F of 28.054] by Prof. Thistlethwaite PA, Li X and others. On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-based therapy for pulmonary arterial hypertension: Rubi Fructus inhibits […]