Regenerative therapy for Diabetes mellitus: 5-aminoimidazole-4-carboxamide riboside (AICAR) promotes an insulin sensitized state via up regulation of reprogramming protein Lin28, 7/April/2015, 10.48 am

A study from the Stem Cell Transplantation Program, Division of Pediatric Hematology/Oncology, Boston Children’s Hospital and Dana Farber Cancer Institute, Boston, Massachusetts, USA shows that “The Lin28/let-7 axis regulates glucose metabolism.” This study was published in the 30 September  2011 issue of the Journal “Cell” [I.F: 33.116]  by Prof Daley GQ, Zhu H, and others. On the foundation of this interesting finding, Dr L […]

Natural product-based Life-span extension therapy: Genistein, an anti-cancer compound isolated from Soya, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span via up regulation of its target gene, 7/April/2015, 9.39 am

A recent study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.” This study was published in the 2 October 2009 issue of the Journal “Science” (I.F: 31.477 )by Prof Dominic J. Withers, Dr. Selman C and others. On the foundation of […]

Molecular therapy for Myeloid leukemia: Deltex1 increases the expression of tumor suppressor protein SPRY4 via down regulation of its target gene, 7/April/2015, 8.26 am

A study from the Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, New York, USA; and Howard Hughes Medical Institute, New York, New York, USA  shows that “Cooperative loss of RAS feedback regulation drives myeloid leukemogenesis.” This study was published in the 30 March  2015 issue of the Journal “Nature Genetics” (the no.1 journal in Genetics with […]

Interleukin-based therapy for Human Cancer: Interleukin-1α (IL-1α) suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) via up regulation of its target gene, 7/April/2014, 7.36 am

The 1989 Nobel prize winner in Chemistry Prof. Thomas R. Cech from the BioFrontiers Institute, USA has published a research paper in the 13 December 2012 Nature (492(7428):285-9; and I.F: >42) stating that “The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity.”  This study provides mechanistic insights into how TPP1 regulates telomerase function. In connection with this finding, Dr Boominathan, Founder Director-cum-chief scientist of GBMD, reports that: Interleukin-based therapy for Human Cancer: Interleukin-1α (IL-1α) suppresses the expression of […]

Regenerative therapy for Diabetes mellitus: Twist increases human pancreatic beta cell replication via down regulation of its target gene DYRK1A, 7/April/2015, 6.35 am

A study from the Diabetes, Obesity and Metabolism Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA and Division of Endocrinology and Bone Disease, Icahn School of Medicine at Mount Sinai, New York, New York, USA  shows that “A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replication.” This […]

Therapeutic insights into increasing Healthspan: MiRNA-509 suppresses the expression of pro-inflammatory protein TNFα via up regulation of its target gene, 6/April/2015, 23.07

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, Therapeutic insights into increasing Healthspan: MiRNA-509 suppresses the expression of pro-inflammatory protein TNFα via up regulation of its target gene, 6/April/2015, 23.07, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Significance: This study suggests, for the first time, that MiRNA-509, by increasing the expression of its target gene, it may suppress the expression of pro-inflammatory […]