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February 13, 2017

Natural product-derived Anti-AXL therapeutics for enhancing the efficacy of chemotherapies: Emodin (6-methyl-1,3,8-trihydroxy anthraquinone), found in Polygonum multiflorum, among others, decreases the expression of the AXL receptor and its activating ligand, GAS6, increases the expression of a number of tumor suppressor genes, increases therapeutic index of anticancer drugs, suppresses tumorigenesis, migration, invasion, and metastasis via up regulation of its target gene, 13/January/2017, 11.34 pm

Introduction: What they say: A study from the Department of Radiation Oncology, Stanford University School of Medicine shows that “Inhibition of the GAS6/AXL pathway augments the […]
February 13, 2017

Anti-ageing therapy: ΔN133p53 increases NMN levels, decreases age-associated weight gain, augments energy metabolism, improves physical activity and insulin sensitivity, promotes healthy lipid profile, and improves eye function via down regulation of its target gene, 13/February/2017, 3.53 pm

Introduction: What they say A study from Gladstone Institute of Neurological Disease and Department of Neurology, University of California, San Francisco, San Francisco, CA 94158, USA […]
February 13, 2017

Natural product therapy for pulmonary arterial hypertension: Shikonin, found in Zicao (also known as purple gromwell), inhibits the development of pulmonary arterial hypertension via down regulation of its target gene Notch3, 13/February/2017, 3.42 pm

What they say:  A study from the University of California, La Jolla, California, USA shows that “Notch3 signaling promotes the development of pulmonary arterial hypertension.” This study was published in the 15 November  2009 issue of the journal “Nature Medicine”[the number […]
February 13, 2017

The PD-L1 pathway blockade enhances the efficacy of Cancer immunotherapy: Atorvastatin, one of the widely used lipid-lowering drug, inhibits the expression of PD-L1, inhibits inflammatory signalling and the number of tumor-infiltrating lymphocytes and macrophages, increases Cytotoxic activity of T-cells, decreases tumor burden and increases survival via up-regulation of its target gene, 13/February/2017, 2.15 pm

Introduction:What they say: A recent study from Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Unit 108, 1515 Holcombe Boulevard, […]
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