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January 7, 2017
Published by admin_auro at January 7, 2017
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Combination therapy for augmenting the anti-cancer drug 5-FU (5-Flurouracil) sensitivity in Human cancers: CGI-58(Comparative gene identification-58)/ABHD5 (α/β-hydrolase domain-containing 5) decreases the expression of the rate-limiting enzyme of the ‘uracil catabolic pathway’ Dihydropyrimidine dehydrogenase (DPYD), increases 5-FU accumulation in cancer cells, augments chemosensitivity, and anti-tumor effect via upregulation of its target gene, 7/January/2017, 11.57 pm

From Research findings to Therapeutic opportunity:  The study presented here suggests that CGI-58/ABHD5, by increasing the expression of its target genes, it may: (i) decrease the expression of Dihydropyrimidine […]
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January 7, 2017
Published by admin_auro at January 7, 2017
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Natural product-derived PD-L1 pathway blockade enhances the efficacy of Cancer immunotherapy: Emodin (6-methyl-1,3,8-trihydroxy anthraquinone), found in Polygonum multiflorum, inhibits inflammatory signalling and the number of tumor-infiltrating lymphocytes and macrophages, increases Cytotoxic activity of T-cells, decreases tumor burden and increases survival via up-regulation of its target gene, 7/January/2017, 11.51 pm

Introduction:What they say: A recent study from Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Unit 108, 1515 Holcombe Boulevard, […]
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January 7, 2017
Published by admin_auro at January 7, 2017
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Life-extension therapy: EF24, a curcumin analog, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 7/January/2017, 11.31 pm

What they say? A study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal […]
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January 7, 2017
Published by admin_auro at January 7, 2017
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Molecular therapy for Myocardial Infarction: MiR-540 inhibits DNA damage responses, increases telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte survival after myocardial infarction via up-regulation of PNUTS, 7/January/2017, 11.10 pm

What they say:  A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published in the 7 March  2013 issue of Nature  by Prof Dimmler, […]
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