Massage therapy for Lifespan extension: Massage inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and increases the expression of longevity gene Sirtuin-1 via its target gene, 24/January/2015, 12.20 pm
A recent study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.” This study was published in the 2 October 2009 issue of the Journal “Science” (I.F: 31.477 ) by Prof Dominic J. Withers, Dr. Selman C and others. On the foundation of […]
MiRNA-based Immune enhancement therapy: MiRNA-504 increases SOX2 expression and promotes innate immunity against bacterial infection via up regulation of its target gene, 24/March/2015, 11.57 am
A recent study from the Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China shows that “Sox2 functions as a sequence-specific DNA sensor in neutrophils to initiate innate immunity against microbial infection.” This study was published in the 2 March 2015 issue of the Journal “Nature Immunology” [I.F: 24.973] by Drs. Zusen Fan, Xia and others. On the […]
Therapeutic insights into the treatment of Stress-induced heart failure: AP-2α protects against stress-induced heart failure via up regulation of SNX13, 24/March/2015, 11.40 am
A recent study from the Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of Medicine, Shanghai 200120, China shows that “SNX13 reduction mediates heart failure through degradative sorting of apoptosis repressor with caspase recruitment domain.” This study was published in the 8 October issue of 2014 Online journal “Nature Communications” by Prof Chen YH, Li […]
Molecular therapy for Metabolic diseases: TAp63 decreases blood pressure and inhibits congestive heart failure via down regulation of angiotensin-converting enzyme (ACE) expression, 24/March/2015, 8.58 am
Significance: This study suggests, for the first time, that TAp63, by increasing the expression of its target gene, it may decrease the expression of angiotensin-converting enzyme (ACE). Thereby, it may: (1) decrease blood pressure; and (2) congestive heart failure. Thus, pharmacological formulations encompassing “TAp63 activators“ may be used to treat patients suffering from metabolic diseases, such as high blood pressure and congestive heart failure. Idea […]
Natural product-based therapy for pulmonary arterial hypertension: Berberine inhibits the development of pulmonary arterial hypertension via down regulation of its target gene, 24/March/2014, 07.17 am
A study from the University of California, La Jolla, California, USA shows that “Notch3 signaling promotes the development of pulmonary arterial hypertension.” This study was published in the 15 November 2009 issue of the journal “Nature Medicine”[the number 1 journal in General Medicine; & I.F: 28.054] by Prof. Thistlethwaite PA, Li X and others. On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-based therapy for pulmonary arterial hypertension: Berberine inhibits the development […]
Molecular therapy for Miscarriage: Lin-28, the RNA binding protein, may inhibit early pregnancy loss and promote fetal growth via down regulation of its target gene, 23/March/2015, 22.26
Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Web: http://genomediscovery.org Significance: This study suggests, for the first time, that Lin-28, by decreasing the expression of its target gene, it may inhibit early pregnancy loss, while promoting fetal growth. Thus, pharmacological formulations encompassing “Lin-28 activators” may be used to protect pregnant women from miscarriage, while promoting fetal growth. […]