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January 2, 2017
Published by admin_auro at January 2, 2017
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Therapeutic insights into “awakening the sleeping/cancer-protecting angels” in mutant p53-expressing human tumors: Pioglitazone (trade name: Actos), an antihyperglycemic drug, increases the expression of tumor suppressor p53 homologue TA-p73/p63, PTEN, TPM1, TIMP3, BTG2, PDCD4, SPRY1/2 and CCM1/KRIT1 and induces regression of p53-mutated human tumors via down regulation of its target gene, 2/January/2017, 8.26 am

From Significance of the study to Public health relevance: Given that: (1) Cancer suppressor p53 is mutated in more than 50% of human cancers of different […]
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January 2, 2017
Published by admin_auro at January 2, 2017
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Life-extension therapy: Rosiglitazone, an antidiabetic medication, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 2/January/2017, 6.15 am

What they say? A study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal […]
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January 1, 2017
Published by admin_auro at January 1, 2017
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Vitamin-based PD-L1 pathway blockade enhances the efficacy of Cancer immunotherapy: δ-tocotrienol (a form of Vitamin-E) inhibits the expression of PD-L1, inhibits inflammatory signalling and the number of tumor-infiltrating lymphocytes and macrophages, increases Cytotoxic activity of T-cells, decreases tumor burden and increases survival via up-regulation of its target gene 1/January/2017, 11.45 pm

Introduction:What they say: A recent study from Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Unit 108, 1515 Holcombe Boulevard, […]
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January 1, 2017
Published by admin_auro at January 1, 2017
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Immune enhancement therapy: Long ncRNA-TUG1 (taurine-upregulated gene) increases SOX2 expression and promotes innate immunity against bacterial infection via down-regulation of its target gene, 1/January/2017, 11.28 pm

Introduction: What they say:   A recent study from the Institute of Biophysics, Chinese Academy of Sciences, Beijing, China shows that “Sox2 functions as a sequence-specific DNA sensor in […]
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