AntagomiR-based therapy for Hypertension: MiRNA-194 increases aldosterone secretion and blood pressure via down regulation of its target gene, Genome-2-Bio-Medicine Discovery center (GBMD), 20/March/2014, 12.26 pm
A study from the Clinical Pharmacology Unit, Department of Medicine, Cardiovascular Division, Department of Medicine (N.F.), University of Cambridge, Addenbrooke’s Hospital, Cambridge, United Kingdom shows that “DACH1, a Zona Glomerulosa Selective Gene in the Human Adrenal, Activates Transforming Growth Factor-β Signaling and Suppresses Aldosterone Secretion.” This study was published in the 16 March 2015 issue of the journal “Hypertension” by Prof. Brown MJ, […]
MiRNA-based therapy for DM: MiRNA-194 regulates gluconeogenesis and hyperglycemia through Cyclin D1, 20/March/2014, 12.03 pm
A study from the Department of Cancer Biology, Dana-Farber Cancer Institute; Department of Cell Biology, Harvard Medical School, USA shows that “Cyclin D1–Cdk4 controls glucose metabolism independently of cell cycle progression.” This study was published in the June 26, 2014 Nature [I.F >35] by Prof. Puigserver and others from the Department of Cancer Biology, Dana-Farber Cancer Institute; Department of Cell Biology, Harvard Medical School, USA. On the foundation of this interesting finding, Dr […]
Natural-product based therapy for Sepsis: Piceatannol, a natural compound found in passion fruit (Passiflora edulis), inhibits lung inflammation by inhibiting inflammasome activation pathway, 20/March/2014, 09.27 am
Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, Natural-product based therapy for Sepsis: Piceatannol, a natural compound found in passion fruit (Passiflora edulis), inhibits lung inflammation by inhibiting inflammasome activation pathway, 20/March/2014, 09.27 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Web: http://genomediscovery.org Courtesy: When you cite drop us a line at info@genomediscovery.org * Research cooperation Significance: Uncontrolled/excessive inflammation is the principle cause of tissue damage […]
Natural product-based anticancer therapy: Ursolic acid, enriched in apples, increases the expression of Sprouty-2 via down regulation of its target gene, 19/March/2015, 22.27
Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, Natural product-based anticancer therapy: Ursolic acid, enriched in apples, increases the expression of tumor suppressor Sprouty-2 via down regulation of its target gene, 19/March/2015, 22.27, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Significance: This study suggests, for the first time, that Ursolic acid, by decreasing the expression of its target gene, it may increase […]
Turning off inflammation inhibits autoimmune myocarditis: Rhamnetin, an O-methylated flavonol isolated from cloves, inhibits cardiac inflammation and injury via down regulation of its target gene, 19/March/2015, 22.19
A recent study from the Department of Cardiology and Pneumology, Charité University Medicine Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, Berlin 12200, Germany shows that “Adiponectin protects against Toll-like receptor 4-mediated cardiac inflammation and injury.” This study was published in the 1 August’13 issue of the Journal “Cardiovascular Research” by Prof. Skurk C., Dr. Jenke A and others. On the foundation of this interesting finding, Dr L Boominathan […]
Mechanistic insight into tumor suppression: Demethylase JMJD3 suppresses the expression of actin-regulatory proteins FHOD1 and PPM1F and inhibits migration and invasion of metastatic cancer cells via up regulation of its target gene, 19/March/2015, 22.11
Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, L., Mechanistic insight into tumor suppression: Demethylase JMJD3 suppresses the expression of actin-regulatory proteins FHOD1 and PPM1F and inhibits migration and invasion of metastatic cancer cells via up regulation of its target gene, 19/March/2015, 22.11, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Significance: The study presented here suggests that JMJD3, by increasing the expression […]