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January 23, 2017
Published by admin_auro at January 23, 2017
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Natural product-derived PD-1 pathway blockade for Human cancer therapy: Isoliquiritigenin, isolated from Licorice (Glycyrrhiza glabra), decreases the activity of Glycogen synthase kinase-3β, increases transcription factor T-bet expression, decreases the abundance of co-inhibitory receptor PD-1 on the cell surface of Cytotoxic-T-cells, increases cytotoxic T lymphocyte function and augments anti-tumor activity, via up-regulation of its target gene, 23/January/2017, 11.52 pm

Introduction:What they say:  A recent study from Cell Signalling Section, Division of Immunology, Department of Pathology, Tennis Court Road, University of Cambridge, Cambridge CB2 1QP, UK […]
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January 23, 2017
Published by admin_auro at January 23, 2017
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Immune enhancement therapy: Insulin increases SOX2 expression and promotes innate immunity against bacterial infection via down-regulation of its target gene, 23/January/2017, 11.38 pm

Introduction: What they say:   A recent study from the Institute of Biophysics, Chinese Academy of Sciences, Beijing, China shows that “Sox2 functions as a sequence-specific DNA sensor in […]
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January 23, 2017
Published by admin_auro at January 23, 2017
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MiRNA therapy for Regenerating the lost pancreatic β-cells in Diabetic patients: MiR-208a promotes an insulin-sensitized state via up-regulation of its target gene, 23/January/2017, 11.33 pm

Introduction: What they say:  A study from the Stem Cell Transplantation Program, Division of Pediatric Hematology/Oncology, Boston Children’s Hospital and Dana-Farber Cancer Institute, Boston, Massachusetts, USA shows that “The […]
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January 23, 2017
Published by admin_auro at January 23, 2017
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Anticancer therapy targeting the cancer stem cells: MiRNA-9600 increases the expression of tumor suppressor INK4a, suppresses proliferation, and promotes apoptosis of cancer cells via down regulation of its target gene, 23/January/2016, 11.21 pm

Research findings to Therapeutic opportunity:   The study presented here suggests that MiRNA-9600, by increasing the expression of its target genes, it may increase the expression of tumor suppressor INK4a. […]
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