MiRNA-based Immune enhancement therapy: CDX2 increases SOX2 expression and promotes innate immunity against bacterial infection via down regulation of its target gene, 10/March/2015, 06.55 am
A recent study from the Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China shows that “Sox2 functions as a sequence-specific DNA sensor in neutrophils to initiate innate immunity against microbial infection.” This study was published in the 2 March 2015 issue of the Journal “Nature Immunology”[I.F: 24.973] by Drs. Zusen Fan, Xia and others. On the foundation […]
MiRNA-based Anti-ageing therapy: MiRNA-486 increases the expression of immortality gene telomerase via down regulation of its target genes, 10/March/2015, 06.41 am
Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, MiRNA-based Anti-ageing therapy: MiRNA-486 increases the expression of immortality gene telomerase via down regulation of its target genes, 10/March/2015, 06.41 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Significance: It has been shown earlier that transgenic expression of telomerase increases the longevity of mice. This study suggests, for the first time, that MiRNA-486, by decreasing […]
Interleukin-based anti-cancer therapy: Interleukin-37 (IL-37) increases the expression of PDCD4 via down regulation of its target gene, 10/March/2015, 06.34 am
Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Web: http://genomediscovery.org Significance: This study suggests, for the first time, Interleukin-37 (IL-37), by suppressing the expression of its target gene, it may increase the expression of tumor suppressor PDCD4. Thus, pharmacological formulations encompassing “IL-37 or its activators” can be used to inhibit the progression of human tumors. Citation: Boominathan, Interleukin-based anti-cancer therapy: Interleukin-37 (IL-37) […]
Molecular therapy for Cancer: MiRNA-146a decreases the expression of immortality gene telomerase via up regulation of its target gene, 9/March/2015, 22.48
Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Web: http://genomediscovery.org Courtesy: When you cite drop us a line at info@genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Significance: This study suggests, for the first time, MiRNA-146a, by suppressing the expression of its target gene, it may decrease the expression of immortality gene telomerase. Thus, pharmacological formulations encompassing “MiRNA-146a activators” can be used to inhibit the progression of human […]
Molecular therapy for Pulmonary neutrophilia: Deubiquitnase DUBA inhibits neutrophil infiltration, decreases mucus production and improves lung function via inhibition of its target gene, 09/March/2015, 22.12
A study from the Department of Molecular Biology, Genentech, 1 DNA Way, South San Francisco, California 94080, USA shows that “Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells.” This study was published in the 19 February 2015 issue of Nature by Prof Dixit VM, Dr. Rutz, and others. On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief […]
Vitamin-based Differentiation Therapy for Embryonal Rhabdomyosarcoma: ATRA (A derivative of Vitamin-A) inhibits the activation of satellite cells and the development of Rhabdomyosarcoma via down regulation of its target gene, 09/February/2015, 18.48
A recent study from Stem Cell Program, Boston Children’s Hospital, Boston, MA, USA; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA; and Harvard Stem Cell Institute, Cambridge, MA, USA shows that “The Hippo Transducer YAP1 Transforms Activated Satellite Cells and Is a Potent Effector of Embryonal Rhabdomyosarcoma Formation.” This study was published in the July 31 2014 Cancer Cell (The number 1 journal in basic Cancer […]