MiRNA based-therapy for pulmonary hypertension: MiRNA-1182 suppresses pulmonary hypertension via up regulation of its target gene, 6/March/2015, 22.06
A recent study from the from the Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, United States of America shows that “High mobility group box 1 contributes to the pathogenesis of experimental pulmonary hypertension via activation of Toll-like receptor 4.“ This study was published in the 8 Feb’13 issue of the Journal Molecular Medicine by Drs. Bauer PM, Bauer EM and others. On […]
Interleukin-based anti-cancer therapy: Interleukin-37 (IL-37) increases the expression of TIMP3 via down regulation of its target gene, 6/March/2015, 22.02
Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Web: http://genomediscovery.org Significance: This study suggests, for the first time, Interleukin-37 (IL-37), by suppressing the expression of its target gene, it may increase the expression of tumor suppressor TIMP3. Thus, pharmacological formulations encompassing “IL-37 or its activators” can be used to inhibit the progression of human tumors. Citation: Boominathan, Interleukin-based anti-cancer therapy: Interleukin-37 (IL-37) […]
MiRNA-based regenerative therapy for Injured tissues: MiRNA-25 promotes epithelial regeneration and tissue growth via downregulation of its target gene, 6/March/2015, 09.18 am
A recent study from the Laboratory of Gene Regulation and Signal Transduction, University of California, San Diego, La Jolla, California 92093; Departments of Pharmacology and Pathology, University of California, San Diego, La Jolla, California 92093; and Moores Cancer Center, University of California, San Diego, La Jolla, California 92093, USA shows that “A gp130-Src-YAP module links inflammation to epithelial […]
Vitamin-based Immune enhancement therapy: Vitamin-E (α-Tocopherol) increases SOX2 expression and promotes innate immunity against bacterial infection via up regulation of its target gene, 6/3/2015, 7.15 am
A recent study from the Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China shows that “Sox2 functions as a sequence-specific DNA sensor in neutrophils to initiate innate immunity against microbial infection.” This study was published in the 2 March 2015 issue of the Journal “Nature Immunology”[I.F: 24.973] by Drs. Zusen Fan, Xia and others. On the […]
Natural product-based therapy for Inflammation-mediated cancers: Allitridin, a main component of Garlic, increases the expression of oncogenic suppressor PTX3 and inhibits complement-dependent inflammation via down regulation of its target gene, 6/March/2015, 07.01 am
A recent study from the Humanitas Clinical and Research Center, Rozzano (Milan) 20089, Italy shows that “PTX3 Is an Extrinsic Oncosuppressor Regulating Complement-Dependent Inflammation in Cancer.” This study was published in the 12 February 2015 issue of the Journal “Cell” [I.F:33] by Drs. Alberto Mantovani , Eduardo Bonavita and others. On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-based […]
Natural product-based therapy for Metastatic tumors: Silvestrol, a compound isolated from the fruits of Aglaia foveolata, decreases the expression of PD-1, a suppressor of activation of T-cells, and activates the immune system via down regulation of its target gene, 6/March/2015, 6.54 am
Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, L., Natural product-based therapy for Metastatic tumors: Silvestrol, a compound isolated from the fruits of Aglaia foveolata, decreases the expression of PD-1, a suppressor of activation of T-cells, and activates the immune system via down regulation of its target gene, 6/March/2015, 6.54 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Significance: It has […]