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January 8, 2017
Published by admin_auro at January 8, 2017
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Small molecule-based PD-1 pathway blockade for Human cancer therapy: Lovastatin (brand name: Mevacor), a hypolipidemic agent, increases transcription factor T-bet expression, decreases the abundance of co-inhibitory receptor PD-1 on the cell surface of Cytotoxic-T-cells, increases cytotoxic T lymphocyte function and augments anti-tumor activity, via up-regulation of its target gene, 8/January/2017, 10.46 pm

Introduction:What they say:  A recent study from Cell Signalling Section, Division of Immunology, Department of Pathology, Tennis Court Road, University of Cambridge, Cambridge CB2 1QP, UK […]
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January 8, 2017
Published by admin_auro at January 8, 2017
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Molecular therapy for triple-negative breast tumors: Lovastatin (brand name: Mevacor), a statin drug used in the treatment of hypercholesterolemia, increases the levels of cell cycle inhibitor, p27, inhibits pro-survival pathways mediated by c-Myc, and inhibits the progression of triple-negative breast cancer via up-regulation of its target gene, 8/January/2017, 9.54 pm

Introduction: What they say A study from the Department of Cell and Tissue Biology, University of California, San Francisco (UCSF), San Francisco, California, USA shows that […]
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January 7, 2017
Published by admin_auro at January 7, 2017
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Combination therapy for augmenting the anti-cancer drug 5-FU (5-Flurouracil) sensitivity in Human cancers: CGI-58(Comparative gene identification-58)/ABHD5 (α/β-hydrolase domain-containing 5) decreases the expression of the rate-limiting enzyme of the ‘uracil catabolic pathway’ Dihydropyrimidine dehydrogenase (DPYD), increases 5-FU accumulation in cancer cells, augments chemosensitivity, and anti-tumor effect via upregulation of its target gene, 7/January/2017, 11.57 pm

From Research findings to Therapeutic opportunity:  The study presented here suggests that CGI-58/ABHD5, by increasing the expression of its target genes, it may: (i) decrease the expression of Dihydropyrimidine […]
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January 7, 2017
Published by admin_auro at January 7, 2017
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Natural product-derived PD-L1 pathway blockade enhances the efficacy of Cancer immunotherapy: Emodin (6-methyl-1,3,8-trihydroxy anthraquinone), found in Polygonum multiflorum, inhibits inflammatory signalling and the number of tumor-infiltrating lymphocytes and macrophages, increases Cytotoxic activity of T-cells, decreases tumor burden and increases survival via up-regulation of its target gene, 7/January/2017, 11.51 pm

Introduction:What they say: A recent study from Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Unit 108, 1515 Holcombe Boulevard, […]
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