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January 3, 2017
Published by admin_auro at January 3, 2017
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Life-extension therapy: Pioglitazone, an antidiabetic medication, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 3/January/2017, 1.41 pm

What they say? A study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal […]
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January 3, 2017
Published by admin_auro at January 3, 2017
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Natural product-derived therapy for H. pylori–induced Gastric cancer: Curcumin, one of the main components of Turmeric, inhibits WNT-SOX9 pathway, decreases oncogenic β-catenin levels, suppresses H. pylori-induced gastric cancer proliferation, inhibits acquisition of tumor-initiating stem-cell properties and decreases chemoresistance via up regulation of its target gene, 3/January/2017, 1.24 pm

From Research findings to Therapeutic opportunity:  The study presented here suggests that Curcumin, by increasing the expression of its target genes, it may: (i) inhibit WNT-SOX9 oncogenic pathway; (ii) decrease oncogenic […]
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January 3, 2017
Published by admin_auro at January 3, 2017
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Natural product-derived Immune enhancement therapy: Oleanolic acid, found in Syzygium S. or Jawa apple and among others, increases SOX2 expression and promotes innate immunity against bacterial infection via down-regulation of its target gene, 3/January/2017, 1.03 pm

Introduction: What they say:   A recent study from the Institute of Biophysics, Chinese Academy of Sciences, Beijing, China shows that “Sox2 functions as a sequence-specific DNA sensor in […]
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January 3, 2017
Published by admin_auro at January 3, 2017
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Natural product-derived combination therapy for augmenting the anti-cancer drug 5-FU (5-Flurouracil) sensitivity in Human cancers: Puerarin, isolated from Cucurbita texana, decreases the expression of the rate-limiting enzyme of the ‘uracil catabolic pathway’ Dihydropyrimidine dehydrogenase (DPYD), increases 5-FU accumulation in cancer cells, augments chemosensitivity, and anti-tumor effect via upregulation of its target gene, 3/January/2017, 11.53 am

What is known? I have published earlier that Puerarin may suppress the expression of Tripeptidyl Peptidase 1 (TPP1) and Telomerase and inhibit cancer progression.  From Research findings […]
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