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November 17, 2016
Published by admin_auro at November 17, 2016
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Therapeutic insights into “awakening the sleeping angel” in mutant p53-expressing human tumors: MiR-9600 increases the expression of tumor suppressor p53 homologue TAp63 and induces regression of p53-mutated human tumors via down regulation of its target gene, 17/November/2016, 10.27 pm

Significance: Cancer suppressor p53 is mutated in more than 50% of human cancers of different origin, while its pathway is altered in about 80% of tumors. […]
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November 17, 2016
Published by admin_auro at November 17, 2016
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Natural product-based therapy for Cardiomyopathy: Apple extract induces the expression of Trbp/miR-208, restores the balance between slow- and fast-twitch myofiber proteins and alleviates Cardiomyopathy via up regulation of its target gene, 17/November/2016, 2.24 pm

Introduction: What they say: A study from the Department of Cardiology, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, USA; and Harvard Stem Cell Institute, Harvard University, Cambridge, […]
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November 17, 2016
Published by admin_auro at November 17, 2016
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Natural product therapy for glucose homeostasis and TIIDM: Oleic acid, found in Safflower, olive, canola, Hazelnut, sunflower oils, Avacados, almond and sunflower among others, increases IKKß and XBP1s activity, decreases the levels of tumor suppressor/stress-responsive proteins, such as PDCD4, and PTEN, reduces ER stress, improves insulin sensitivity, promotes glucose homeostasis and prevents the progression of TIIDM via up regulation of its target gene, 17/November/2015, 8.30 am

What they say:  A study from the Division of Endocrinology, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02130, USA; Laboratory of Gene Regulation and Signal […]
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November 17, 2016
Published by admin_auro at November 17, 2016
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Natural product-based PD-1 pathway blockade for Human cancer therapy: Ginsenoside, isolated from Ginseng herb, inhibits the expression of co-inhibitory receptor PD-1 on Antigen- Specific T-cells, increases the production of cytokines by tumor-infiltrating lymphocytes (TIL), and draining lymph nodes and augments anti-tumor activity via down-regulation of its target gene, 17/November/2016, 7.18 am

Introduction:What they say:  A recent study from Division of Infectious Diseases, School of Medicine, Johns Hopkins University, Baltimore, MD 21218, United States shows that “TGF-β1-Mediated Smad3 […]
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