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January 3, 2017
Published by admin_auro at January 3, 2017
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Small molecule-based PD-1 pathway blockade for Human cancer therapy: Linagliptin (brand name: BI-1356/Tradjenta), an inhibitor of dipeptidylpeptidase-4 (DPP-4), increases transcription factor T-bet expression, decreases the abundance of co-inhibitory receptor PD-1 on the cell surface of Cytotoxic-T-cells, increases cytotoxic T lymphocyte function and augments anti-tumor activity, via up-regulation of its target gene, 3/January/2017, 5.12 pm

Introduction:What they say:  A recent study from Cell Signalling Section, Division of Immunology, Department of Pathology, Tennis Court Road, University of Cambridge, Cambridge CB2 1QP, UK […]
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January 3, 2017
Published by admin_auro at January 3, 2017
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Cardiac rejuvenation therapy: AML-3 (Cbfa1/Runx2) suppresses tumor suppressor INK4a/p16 expression, and inhibits dilated cardiomyopathy and heart failure via up regulation of its target gene, 3/January/2017, 2.09 pm

Introduction: What they say A recent study from the Stem Cell Aging Group, Centro Nacional de Investigaciones Cardiovasculares, E-28029 Madrid, Spain shows that “Bmi1 limits dilated […]
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January 3, 2017
Published by admin_auro at January 3, 2017
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Life-extension therapy: Pioglitazone, an antidiabetic medication, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 3/January/2017, 1.41 pm

What they say? A study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal […]
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January 3, 2017
Published by admin_auro at January 3, 2017
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Natural product-derived therapy for H. pylori–induced Gastric cancer: Curcumin, one of the main components of Turmeric, inhibits WNT-SOX9 pathway, decreases oncogenic β-catenin levels, suppresses H. pylori-induced gastric cancer proliferation, inhibits acquisition of tumor-initiating stem-cell properties and decreases chemoresistance via up regulation of its target gene, 3/January/2017, 1.24 pm

From Research findings to Therapeutic opportunity:  The study presented here suggests that Curcumin, by increasing the expression of its target genes, it may: (i) inhibit WNT-SOX9 oncogenic pathway; (ii) decrease oncogenic […]
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