Natural product-based anticancer therapy: Ursolic acid increases the expression of tumor suppressor KRIT1/CCM1 via down regulation of its target gene, 22/February/2015, 23.06

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, Natural product-based anticancer therapy: Ursolic acid increases  the expression of tumor suppressor KRIT1/CCM1 via down regulation of its target gene, 22/February/2015, 23.06, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Significance: This study suggests, for the first time, that Ursolic acid, by decreasing the expression of its target gene, it may increase the expression of […]

Treating Metastatic tumors with Fish oil: DHA (Docosahexaenoic acid), the bio-active fish oil component, suppresses the expression of PD-1, a suppressor of activation of T-cells, and activates the immune system via down regulation of its target gene, 22/February/2015, 23.02

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, Treating Metastatic tumors with Fish oil:  DHA (Docosahexaenoic acid), the bio-active fish oil component, suppresses the expression of PD-1, a suppressor of activation of T-cells, and activates the immune system via down regulation of its target gene, 22/February/2015, 23.00, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Significance: It has recently been shown that blocking PD-1 […]

Molecular therapy for Cancer: Deubiquitnase DUBA suppresses intestinal tumorigenesis via inhibition of IL-17-mediated oncogenic signalling, 22/February/2015, 16.50

A study from the Laboratory of Gene Regulation and Signal Transduction, Departments of Pharmacology and Pathology, School of Medicine, University of California, San Diego, Gilman Drive, La Jolla, CA 92093-0723, USA shows that “Interleukin-17 receptor a signaling in transformed enterocytes promotes …tumorigenesis.” This study was published in the 14 December  2014 issue of Immunity by Prof Michael Karin, Dr. Wang K, and […]

Mechanistic insight into Regulation of Ribosome biogenesis: NR2F2 suppresses the expression of RNA polymerase I via down regulation of its target gene, 22/February/2015, 16.24

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, Mechanistic insight into Regulation of Ribosome biogenesis: NR2F2 suppresses the expression of RNA polymerase I via down regulation of its target gene, 22/February/2015, 16.24, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Significance: This study suggests, for the first time, that tumor suppressor NR2F2, by increasing the expression of  its target gene, it may decrease […]

Mechanistic insights into tumor suppression: Ribosomal protein L11 suppresses the expression of immortality gene telomerase via down regulation of its target gene, 22/February/2015, 16.20

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, Mechanistic insights into tumor suppression: Ribosomal protein L11 suppresses the expression of immortality gene telomerase via down regulation of its target gene, 22/February/2015, 16.20, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Significance:  This study suggests, for the first time, that Ribosomal protein L11, by suppressing the expression of its target gene, it may decrease […]

Mechanistic insights into tumor suppression: Ribosomal protein S14 suppresses the expression of oncomiR 17-92 via down regulation of its target gene, 22/February/2015, 16.14

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, Mechanistic insights into tumor suppression: Ribosomal protein S14 suppresses the expression of oncomiR 17-92 via down regulation of its target gene, 22/February/2015, 16.14, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Significance:  This study suggests, for the first time, that Ribosomal protein S14, by suppressing the expression of its target gene, it may decrease the […]