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December 9, 2016

Natural product-derived therapy for brain repair and Lifespan extension: Dehydroleucodine, a Sesquiterpene Lactone from Gynoxys verrucosa and Artemisia douglassiana Besser, increases VGF and BDNF expression, promotes Oligodendrocytes (OP) proliferation, triggers myelination on neurons, reverts neural damage, produces antidepressant like effects, and prolongs lifespan via up-regulation of its target gene, 9/December/2016, 10.34 pm

What they say: Introduction:   A recent study from the Department of Biochemistry & Molecular Pharmacology, Smilow Research Center, Howard Hughes Medical Institute, NYU School of […]
December 9, 2016

Natural product-derived therapy for overcoming chemoresistance in Human cancers: Rhamnetin, found in cloves, increases the expression of CADM1, decreases BMI1 translocation, increases tumor suppressor INK4a/p16 expression and restores chemosensitivity in drug-resistant Human cancers via down regulation of its target gene, 9/December/2016, 10.07 pm

From Research findings to Therapeutic opportunity:  The study presented here suggests that Rhamnetin, by increasing the expression of its target genes, it may: (i) increase the expression of CADM1; […]
December 9, 2016

Natural product-derived Lifespan extension therapy: 2,4,5-trihydroxybenzaldehyde (TDB), found in Geum japonicum and Polygonum cuspidatum (PC), also known as Japanese knotweed, increases life span via up-regulation of its target gene BubR1, 09/December/2016, 11.56 am

 What they say: Introduction:  A recent study from the Department of Genetics, Paul F. Glenn Laboratories for the Biological Mechanisms of Aging Harvard Medical School, Boston,USA; and […]
December 9, 2016

Therapeutic insights into “awakening the sleeping/cancer-protecting angels” in mutant p53-expressing human tumors: MiR-486 increases the expression of tumor suppressor p53 homologue TA-p73/p63, PTEN, TPM1, TIMP3, BTG2, PDCD4, and SPRY1/2 and induces regression of p53-mutated human tumors via down regulation of its target gene, 9/December/2016, 10.53 am

From Significance of the study to Public health relevance: Given that: (1) Cancer suppressor p53 is mutated in more than 50% of human cancers of different […]
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