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December 22, 2016
Published by admin_auro at December 22, 2016
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Natural product-derived PD-L1 pathway blockade enhances the efficacy of Cancer immunotherapy: Withaferin A, a lactone isolated from herb Withania Somnifera/Ashwagandha and Acnistus arborescens, inhibits the expression of PD-L1, inhibits inflammatory signalling and the number of tumor-infiltrating lymphocytes and macrophages, increases Cytotoxic activity of T-cells, decreases tumor burden and increases survival via up-regulation of its target gene, 22/December/2016, 8.29 pm

Introduction:What they say: A recent study from Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Unit 108, 1515 Holcombe Boulevard, […]
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December 21, 2016
Published by admin_auro at December 21, 2016
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Small molecule-based PD-1 pathway blockade for Human cancer therapy: NQO1 (NAD(P)H dehydrogenase [quinone] ) inhibits the expression of co-inhibitory receptor PD-1 on Antigen- Specific T-cells, increases the production of cytokines by tumor-infiltrating lymphocytes (TIL), and draining lymph nodes and augments anti-tumor activity via down-regulation of its target gene, 21/December/2016, 11.30 pm

Introduction:What they say: A recent study from Division of Infectious Diseases, School of Medicine, Johns Hopkins University, Baltimore, MD 21218, United States shows that “TGF-β1-Mediated Smad3 […]
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December 21, 2016
Published by admin_auro at December 21, 2016
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Molecular therapy for Myocardial Infarction: Lithium, the widely used drug in the treatment of depressive/bipolar disorders, inhibits DNA damage responses, increases telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte survival after myocardial infarction via up-regulation of PNUTS, 21/December/2016, 11.07 pm

What they say:  A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published in the 7 March  2013 issue of Nature  by Prof Dimmler, […]
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December 21, 2016
Published by admin_auro at December 21, 2016
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Immune enhancement therapy: Lithium increases SOX2 expression and promotes innate immunity against bacterial infection via down-regulation of its target gene, 21/December/2016, 10.43 pm

Introduction: What they say: A recent study from the Institute of Biophysics, Chinese Academy of Sciences, Beijing, China shows that “Sox2 functions as a sequence-specific DNA sensor in neutrophils […]
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