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October 10, 2016
Published by admin_auro at October 10, 2016
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Natural product-based PD-1 pathway blockade for Human cancer therapy: Berberine inhibits the expression of co-inhibitory receptor PD-1 on Antigen- Specific T-cells, increases the production of cytokines by tumor-infiltrating lymphocytes (TIL), and draining lymph nodes and augments anti-tumor activity via down-regulation of its target gene, 10/october/2016, 7.28 am

A recent study from Division of Infectious Diseases, School of Medicine, Johns Hopkins University, Baltimore, MD 21218, United States shows that “TGF-β1-Mediated Smad3 Enhances PD-1 Expression […]
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October 10, 2016
Published by admin_auro at October 10, 2016
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Therapeutic insights into “awakening the sleeping angel” in mutant p53-expressing human tumors: Curcumin, one of the main components of turmeric, increases the expression of tumor suppressor p53 homologue TAp63γ and induces regression of p53-mutated human tumors via downregulation of its target gene, 10/October/2016, 6.24 am

Significance: Cancer suppressor p53 is mutated in more than 50% of human cancers of different tissue origin, while its pathway is altered in about 80% of […]
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October 9, 2016
Published by admin_auro at October 9, 2016
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Life-extension therapy: Cantharidin inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span via upregulation of its target genes, 9/October/2016, 11.14 pm

A recent study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal protein S6 […]
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October 9, 2016
Published by admin_auro at October 9, 2016
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Natural product-based therapy for Idiopathic pulmonary fibrosis: Ajoene, found in Garlic, increases TRF1 expression and ameliorates pulmonary fibrosis via upregulation of its target gene, 9/October/2015, 10.48 pm

A study from the Spanish National Cancer Centre, Melchor Fernández Almagro 3, Madrid, Spain“ shows that: “Mice with Pulmonary Fibrosis Driven by Telomere Dysfunction.” This study was published in the 14 July 2015 issue of […]
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