Insights into High glucose-induced pulmonary arterial hypertension: High glucose promotes the development of pulmonary arterial hypertension via down regulation of its target gene, 25/January/2014, 22.29

A study from the University of California, La Jolla, CA, USA shows that “Notch3 signaling promotes the development of pulmonary arterial hypertension.” This study was published in the 15 November  2009 issue of Nature Medicine by Prof. Thistlethwaite PA, Li X and others. On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Insights into High glucose-induced pulmonary arterial hypertension: High glucose promotes the development of pulmonary arterial hypertension via down regulation of its target gene. This study provides […]

Vitamin-based Neuron replacement therapy for Neurodegenerative diseases: Vitamin-E promotes neuronal cell conversion from differentiated cells via up regulation of its target gene, 25/November/2014, 22.20

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Web: http://genomediscovery.org Significance: This study suggests that Vitamin-E, by suppressing the expression of its target gene, it may convert the differentiated cells into Neuronal cells. Together, pharmacological formulations encompassing “Vitamin-E or its analogues” may be used in the treatment of Neurodegenerative diseases. Amount: $ 500 Undisclosed information: How Vitamin-E promotes neuronal conversion from differentiated cells Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ To […]

Molecular therapy for Cancer: Grhl3 increases the expression of tumor suppressor FBXO11 via down regulation of its target gene, 25/January/2015, 21.42

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, Molecular therapy for Cancer: Grhl3 increases the expression of tumor suppressor FBXO11 via down regulation of its target gene, 25/January/2015, 21.42, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Significance: This study suggests, for the first time, that Grhl3, by suppressing the expression of its target gene, it may promote the activity of tumor suppressor FBXO11. Thus, pharmacological […]

Molecular cancer therapy for breast cancer: NRF2 suppresses the expression Sema4c, epithelial-mesenchymal transition and chemotherapeutic resistance via up regulation of its target gene, 25/January/20145, 21.37

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, Molecular cancer therapy for breast cancer: NRF2 suppresses the expression Sema4c, epithelial-mesenchymal transition and chemotherapeutic resistance via up regulation of its target gene, 25/January/20145, 21.37, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Significance: This study suggests, for the first time, that NRF2, by increasing the expression of its target gene, it may suppress the expression […]

MNatural product-based therapy for Stroke: Garlic inhibits cerebral ischemia induced injury via down regulation of its target gene, 25/January/2015, 21.34

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, Natural product-based therapy for Stroke: Garlic inhibits cerebral ischemia induced injury via down regulation of its target gene, 25/January/2015, 21.34, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Significance: This study suggests, for the first time, that Garlic, by suppressing the expression of its target gene, it may inhibit cerebral ischemia induced injury.  Thus, pharmacological formulations encompassing “Garlic […]

AntagomiR-based therapy for T2DM: MiRNA-150 promotes glucose intolerance and insulin resistance via down regulation of its target gene, 24/January/2015, 23.50

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, AntagomiR-based therapy for T2DM: MiRNA-150 promotes glucose intolerance and insulin resistance via down regulation of its target gene, 24/January/2015, 23.50, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Significance: This study suggests, for the first time, that MiRNA-150, by suppressing the expression of its target gene, it may promote glucose intolerance and insulin resistance.  Thus, pharmacological formulations encompassing “miRNA-150 […]