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April 27, 2015

The Exercise-Mimicking pills may inhibit Insulin resistance and decrease adiposity: HMGB1 decreases gluconeogenesis genes, such as PEPCK and G6Pase, reduces hepatic glucose production, improves muscle insulin sensivitity and decreases adiposity via up regulation of its target gene, 27/April/2015, 8.01 am

Significance: This study suggests, for the first time, that HMGB1, by increasing the expression of its target gene, it may: (1) decrease the expression of gluconeogenesis genes, such […]
April 27, 2015

Molecular therapy for Metastatic human tumors: Ndfip1 decreases cellular proliferation, invasion and metastasis by increasing the expression of metastasis suppressor TIMP3 via down regulation of its target gene, 27/April/2015, 7.00 am

A study from the Cell Pathology Division, The Children’s Hospital of Philadelphia, Philadelphia, USA shows that “TGF-β induces the expression of the adaptor Ndfip1 to silence IL-4 production […]
April 26, 2015

Natural product-based therapy for Metastatic Pancreatic/intestine/ovarian Cancers: Curcumin, the major component of turmeric, suppresses the expression of PDGF Receptor β (PDGFRβ) via down regulation of its target gene, 27/April/2015, 12.20 am

A study from Watson School of Biological Sciences shows that Mutant p53 Drives Pancreatic Cancer Metastasis through Cell-Autonomous PDGF Receptor β Signaling. This study was published in the April 10, […]
April 26, 2015

MiRNA-based therapy for pulmonary arterial hypertension: MiRNA-709 inhibits the development of pulmonary arterial hypertension via down regulation of its target gene Notch3, 26/April/2015, 23.52

A study from the University of California, La Jolla, California, USA shows that “Notch3 signaling promotes the development of pulmonary arterial hypertension.” This study was published in the 15 November  2009 issue of the journal “Nature Medicine”[the number 1 journal in […]
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