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April 24, 2015

Mechanistic insight into tumorigenesis: Orphan Nuclear receptor NUR77 increases the expression of MDM2, a negative regulator of stress responsive protein p53, via up regulation of its target gene, 24/April/2015, 21.43

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, Mechanistic insight into tumorigenesis: Orphan Nuclear receptor NUR77 increases the expression of MDM2, a negative regulator of stress […]
April 24, 2015

MiRNA-based Exercise-Mimicking pill may inhibit Insulin resistance: MiRNA-96 decreases gluconeogenesis genes, such as PEPCK and G6Pase, reduces hepatic glucose production, and improves insulin sensivitity via down regulation of its target gene, 24/April/2015, 12.57 pm

Significance: This study suggests, for the first time, that MiRNA-96, by decreasing the expression of its target gene, it may: (1) decrease the expression of gluconeogenesis genes, such […]
April 24, 2015

Stalling metastatic cancer spread by exposing it to the Sunlight: Calcitriol (1α, 25-dihydroxyvitamin D3) increases the expression of tumor suppressor RECK and inhibits migration and invasion of metastatic cancer cells via down regulation of its target gene, 24/April/2015, 12.20 pm

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Significance: This study suggests a vitamin-based Anti-metastasis therapy. 1α, 25-dihydroxyvitamin D3 (Calcitriol), by increasing the expression of its target genes, […]
April 24, 2015

Natural product-based therapy for pulmonary arterial hypertension: Cinnamaldehyde (CA) inhibits the development of pulmonary arterial hypertension via down regulation of its target gene Notch3, 24/April/2015, 7.59 am

A study from the University of California, La Jolla, California, USA shows that “Notch3 signaling promotes the development of pulmonary arterial hypertension.” This study was published in the 15 November  2009 issue of the journal “Nature Medicine”[the number 1 journal in […]
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