Therapeutic insights into increasing the life expectancy of Males: Mangiferin, a compound isolated from Mango, increases male longevity via up regulation of longevity-promoting gene Sirtuin-1, 23/October/2014, 9.19 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, Therapeutic insights into increasing the life expectancy of Males: Mangiferin, a compound isolated from Mango, increases male longevity via up regulation of longevity-promoting gene Sirtuin-1, 23/October/2014, 9.19 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Significance:  Numerous studies show that Mango has health benefits. This study suggests, for the first time, that Mangiferin, by increasing the expression […]

Mechanistic and Therapeutic insights into Cardiac reprogramming: Mef2 promotes the generation of cardiomyocyte-like cells from differentiated cells by decreasing Snai1/Snail expression, 23/October/2014, 9.14 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Web: http://genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ To cite: Boominathan, Mechanistic and Therapeutic insights into Cardiac reprogramming: Mef2 promotes the generation of cardiomyocyte-like cells from differentiated cells by decreasing Snai1/Snail expression, 23/October/2014, 9.14 am,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Significance: This study suggests that Mef2, by increasing the expression of its target gene, it could increase the number of beating cardiomyocyte-like cells (iCMs).  Taken together, this study suggests […]

Cold temperature favors reprogramming of testes to ovaries: Cold temperature decreases the expression of testis specific gene SRY target gene Sox9 via down regulation of its target gene, 22/October/2014, 20.24

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Citation: Boominathan, L., Cold temperature favors reprogramming of testes to ovaries: Cold temperature decreases the expression of testis specific gene SRY target gene Sox9 via down regulation of its target gene, 22/October/2014, 20.24, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Significance: This study suggests, for first time, that cold temperature, by decreasing the expression of its target gene, it […]

Therapeutic insights into making the highly efficient cardiomyocyte-like cells from differentiated cells: Reversine inhibits cardiac reprogramming by increasing Snai expression, 22/October/2014, 20.17

A study from the Department of Clinical and Molecular Cardiovascular Research, Keio University School of Medicine, Shinjuku-ku Tokyo, Japan;  and Department of Cardiology, Keio University School of Medicine, Shinjuku-ku Tokyo, Japan;  and  JST CREST, Shinjuku-ku Tokyo, Japan has reported that “MiR-133 promotes cardiac reprogramming by directly repressing Snai1 and silencing …” This study was published in the June 2014 issue of EMBO […]

Anti-metastasis therapy: GATA binding protein-6 inhibits invasive motility via down regulation of ICAT (Inhibitor of β-catenin and TCF), 22/October/2014, 20.09

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Citation: Boominathan, L., Anti-metastasis therapy: GATA binding protein-6 inhibits invasive motility via down regulation of ICAT (Inhibitor of β-catenin and TCF), 22/October/2014, 20.09, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Significance: This study suggests that GATA binding protein-6, by increasing the expression of its target gene, it may decrease the expression of EMT protein ICAT.  Therefore, pharmacological formulations encompassing “GATA binding protein-6 activators“ may be […]

MiRNA-based therapy for cancer: MiRNAs-99 and -100 suppress the expression of Notch1 and Notch2 via up regulation of their target gene, 22/October/2014, 20.05, 22/October/2014, 20.05

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Citation: Boominathan, MiRNA-based therapy for cancer:  MiRNAs-99 and -100 suppress the expression of Notch1 and Notch2 via up regulation of their target gene, 22/October/2014, 20.05, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Significance: This study suggests that MiRNAs-99 and -100, by increasing the expression of their target gene,  they may suppress the expression of Notch1 and Notch2.  Thus, pharmacological formulations encompassing “miRs-99 and […]