August 20, 2017

Natural product-derived therapy for therapy-resistant cancers: A therapeutic mix encompassing N-AcetylCysteine (NAC), Capsaicin and Sulforaphane inhibits the expression of phospholipid glutathione peroxidase (GPX4), inhibits GPX4 signaling network and lipid peroxidase pathway, suppresses EMT protein ZEB1, increases sensitivity to anticancer therapy and prolongs survival via up regulation of its target gene, 21/August/2017, 12.10 am

Introduction: What they say: A study from Broad Institute, Cambridge, Massachusetts, USA, Howard Hughes Medical Institute, Chevy Chase, Maryland and Department of Chemistry and Chemical Biology, […]
August 19, 2017

Molecular therapy for Metastatic cancers: Ivermectin, the anthelmintic drug, increases the expression of metastasis suppressors  PTEN and PDCD4, inhibits cell cycle progression, and suppresses migration, invasion and metastasis of cancer cells via up regulation of its target gene, 19/August/2017, 12.40 am

From Significance of the study to Public health relevance: Given that: (i) each year nearly 14 million people are diagnosed with cancer globally, and little more […]
August 19, 2017

Natural product-derived CMTM6/4-PD-L1 pathway blockade enhances the efficacy of Cancer immunotherapy: A therapeutic mix encompassing Honokiol and Magnolol, isolated from Magnolia grandiflora/dealbata/obovata/officinalis, inhibits the expression of transmembrane protein CMTM6/CMTM4, increases interferon-IFNγ signalling, augments antigen presentation and unfolding response, increases Cytotoxic activity of T-cells, decreases tumor burden and increases survival via up-regulation of its target gene, 19/August/2017, 11.58 pm

Introduction:What they say: A recent study from Division of Molecular Oncology & Immunology, The Netherlands Cancer Institute, Plesmanlaan, CX Amsterdam, The Netherlands has identified CMTM6 and […]
August 19, 2017

Molecular therapy for metastatic prostate cancer: A therapeutic mix encompassing Nimbolide and N-Acetyl Cysteine (NAC)   inhibits the expression of CDC42, CDC42EP3, RAC1 and ARPC5, and GAS6, suppresses the expression of stem cell molecules CD44 and EZH2, promotes epithelial phenotype, suppresses tumorigenesis, migration, invasion, stem cell regeneration and metastasis via up regulation of its target gene, 18/August/2017, 10.46 pm

Introduction: What they say: A study from the Department of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center, Science Park, Texas 78957, USA […]