Cardiac regeneration

August 29, 2019

Polypill to protect against cardiovascular dysfunction, including cardiac hypertrophy and fibrosis: A four-component Polypill consisting of Hydrochlorothiazide (12·5 mg), Aspirin (81 mg), Atorvastatin (20 mg), and Enalapril (5 mg) or Valsartan (40 mg) [Polypill-HAAE/HAAV] decreases MiR-29 expression, activates wnt- signaling and its components GSK3B, ICAT/CTNNBIP1, HBP1, and GLIS2, attenuates pathologic hypertrophy, inhibits fibrosis of the heart tissue, and improves cardiac function, via up regulation of its target gene, 30/August/2019, 12.03 am

Introduction: What they say:   A recent study from the Institute of Pharmacology and Toxicology, Technical University Munich (TUM), 80802, Munich, Germany; DZHK (German Center for Cardiovascular […]
August 28, 2019

Why cigarette smoking is not good for your heart: Mechanistic  and functional insights into how cigarette smoking accelerates cardiac dysfunction: Cigarette smoking augments DNA damage responses, attenuates telomerase expression, promotes telomere shortening, and attenuates cardiomyocyte survival after myocardial infarction, via down regulation of PNUTS and others, 28/August/2019, 1.55 pm

What they say:  A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published, in the 7 March  2013 issue of of […]
July 12, 2019

Little RNA can protect your heart from Myocardial diseases: LncRNA MIRT2 (Myocardial infarction-associated transcript 2 (Mirt2)-based therapy for Cardiac repair and myocardial infarction: LncRNA  Mirt2  increases Agrin expression, activates Yap and ERK-mediated signaling,  replaces scar tissue with functional cardiomyocytes, and promotes cardiomyocyte regeneration and repair after myocardial infarction, via up-regulation of its target gene, 12/July/2019, 11.47 pm

Introduction: What they say: A recent study from Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel; Department of Biomedical Engineering, Duke University, […]
July 10, 2019

Little RNA can better your heart functioning: LncRNA Mirt2 -based Regenerative therapy for regaining the lost cardiomyocytes in Myocardial patients: LncRNA Mirt2 (Myocardial infarction-associated transcript 1 (Mirt1) increases the expression of ERBB2/Her2 and promotes dedifferentiation  of cardiomyocytes, via up-regulation of its target gene, 10/July/2019, 11.41 am

Introduction: What they say A recent study from the Department of Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel shows that “ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte dedifferentiation and proliferation.” This study was […]