Category Archives: Ideas

Natural product-derived Lifespan extension therapy: Genistein, an isoflavone isolated from Soy products, prolongs mammalian life span via down regulation of angiotensin II type I receptor (AT1R), 26/March/2017, 6.33 am

Significance of the study: It has been shown earlier that antagonizing angiotensin II type I receptor (AT1R) expression may prolong mammalian life span. Further, it has been shown that disruption of AT1R (AGTR1) gene results in marked prolongation of mammalian lifespan.  From research … Continue reading

Posted in Ideas | Comments Off on Natural product-derived Lifespan extension therapy: Genistein, an isoflavone isolated from Soy products, prolongs mammalian life span via down regulation of angiotensin II type I receptor (AT1R), 26/March/2017, 6.33 am

Molecular therapy for the lost pancreatic β-cells in Diabetic patients: Zebularine plus Scriptaid treatment promotes an insulin-sensitized state via up-regulation of its target gene Lin-28, 25/March/2017, 11.26 pm

What we say:  Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Molecular therapy for the lost pancreatic β-cells in Diabetic patients: Zebularine plus Scriptaid treatment promotes an insulin-sensitized state via up-regulation of  its target gene Lin-28 From Significance of the study to Public … Continue reading

Posted in Ideas | Comments Off on Molecular therapy for the lost pancreatic β-cells in Diabetic patients: Zebularine plus Scriptaid treatment promotes an insulin-sensitized state via up-regulation of its target gene Lin-28, 25/March/2017, 11.26 pm

Vitamin therapy for pulmonary arterial hypertension: Ascorbate(Vitamin-C), found abundantly in Kakadu plum, Camu Camu, yellow pepper, and amla, among others, inhibits the development of pulmonary arterial hypertension via down regulation of its target gene Notch3, 25/February/2017, 10.58 pm

What they say:  A study from the University of California, La Jolla, California, USA shows that “Notch3 signaling promotes the development of pulmonary arterial hypertension.” This study was published in the 15 November  2009 issue of the journal “Nature Medicine”[the number 1 journal in General Medicine with an I.F of 28.054] by Prof. Thistlethwaite PA, Li X and others. What … Continue reading

Posted in Ideas | Comments Off on Vitamin therapy for pulmonary arterial hypertension: Ascorbate(Vitamin-C), found abundantly in Kakadu plum, Camu Camu, yellow pepper, and amla, among others, inhibits the development of pulmonary arterial hypertension via down regulation of its target gene Notch3, 25/February/2017, 10.58 pm

Natural product-derived therapy for Metastatic human tumors: Diosmetin, a flavone aglycone found in lemons, decreases the expression of c-Src protein, inhibits the expression of a number of enzymes in glycolytic cycle, and suppresses proliferation, migration, invasion, tumorigenesis and metastasis via up regulation of its target gene, 25/March/2017, 10.37 pm

Introduction: What they say: A study from the State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, Fujian 361102, China shows that “c-Src phosphorylation and activation of hexokinase promotes … Continue reading

Posted in Ideas | Comments Off on Natural product-derived therapy for Metastatic human tumors: Diosmetin, a flavone aglycone found in lemons, decreases the expression of c-Src protein, inhibits the expression of a number of enzymes in glycolytic cycle, and suppresses proliferation, migration, invasion, tumorigenesis and metastasis via up regulation of its target gene, 25/March/2017, 10.37 pm

Molecular therapy for pulmonary fibrosis: Taurine decreases miR-34 expression, increases Sirtuin-1 expression, suppresses tumor suppressor p53 acetylation, prevents apoptosis in Alveolar epithelial cell (AEC), and improves pulmonary fibrosis via down regulation of its target gene, 25/March/2017, 1.20 pm

What we say:  Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Molecular therapy for pulmonary fibrosis: Taurine decreases miR-34 expression, increases Sirtuin-1 expression, suppresses tumor suppressor p53 acetylation, prevents apoptosis in Alveolar epithelial cell (AEC), and improves pulmonary fibrosis via down … Continue reading

Posted in Ideas | Comments Off on Molecular therapy for pulmonary fibrosis: Taurine decreases miR-34 expression, increases Sirtuin-1 expression, suppresses tumor suppressor p53 acetylation, prevents apoptosis in Alveolar epithelial cell (AEC), and improves pulmonary fibrosis via down regulation of its target gene, 25/March/2017, 1.20 pm

Natural product-derived therapy for Allergic rhinitis: Naringenin, found in Grape fruits, inhibits GM-CSF, Interleukin 13 receptor(IL-13)-Rα1, and eotaxin expression, among others, inhibits mucus production and alleviates allergic rhinitis via up regulation of its target gene, 25/March/2017, 1.02 pm

What we say: Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-derived therapy for Allergic rhinitis: Naringenin, found in Grape fruits,  inhibits GM-CSF, Interleukin 13 receptor(IL-13)-Rα1, and eotaxin expression, among others, inhibits mucus production and alleviates allergic rhinitis via … Continue reading

Posted in Ideas | Comments Off on Natural product-derived therapy for Allergic rhinitis: Naringenin, found in Grape fruits, inhibits GM-CSF, Interleukin 13 receptor(IL-13)-Rα1, and eotaxin expression, among others, inhibits mucus production and alleviates allergic rhinitis via up regulation of its target gene, 25/March/2017, 1.02 pm

Natural product-derived therapy for glucose homeostasis and TIIDM: Berberine, found in Berberis, Berberis aristata, Hydrastis canadensis, Phellodendron amurense, and Argemone mexicana among others, increases Barr2 expression, augments the functional activity of CAMKII, increases insulin secretion, promotes glucose homeostasis, prevents progression to TIIDM and ameliorates obesity-associated metabolic deficits via down regulation of its target gene, 24/March/2017, 10.53 pm

Introduction: What they say A study from the Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892, USA shows that “ß-arrestin-2 is an essential regulator of pancreatic ß-cell function under … Continue reading

Posted in Ideas | Comments Off on Natural product-derived therapy for glucose homeostasis and TIIDM: Berberine, found in Berberis, Berberis aristata, Hydrastis canadensis, Phellodendron amurense, and Argemone mexicana among others, increases Barr2 expression, augments the functional activity of CAMKII, increases insulin secretion, promotes glucose homeostasis, prevents progression to TIIDM and ameliorates obesity-associated metabolic deficits via down regulation of its target gene, 24/March/2017, 10.53 pm

Natural product-derived Lifespan extension therapy: Berberine, found in Berberis, Berberis aristata, Hydrastis canadensis, Phellodendron amurense, and Argemone mexicana, among others, prolongs mammalian life span via down regulation of angiotensin II type I receptor (AT1R), 24/March/2017, 7.00 pm

Significance of the study: It has been shown earlier that antagonizing angiotensin II type I receptor (AT1R) expression may prolong mammalian life span. Further, it has been shown that disruption of AT1R (AGTR1) gene results in marked prolongation of mammalian lifespan.  From research … Continue reading

Posted in Ideas | Comments Off on Natural product-derived Lifespan extension therapy: Berberine, found in Berberis, Berberis aristata, Hydrastis canadensis, Phellodendron amurense, and Argemone mexicana, among others, prolongs mammalian life span via down regulation of angiotensin II type I receptor (AT1R), 24/March/2017, 7.00 pm

Natural product-derived therapy for Human cancers: Shikonin, one of the main components of herb Zicao, increases the expression of mitochondrial protein LACTB, decreases levels of mitochondrial phosphatidylserine decarboxylase, alters mitochondrial lipid metabolism, and promotes differentiation of breast cancer cells via up-regulation of its target gene, 24/March/2017, 6.37 pm

Introduction: What they say: A study from the Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts, USA Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA; MIT Ludwig Center for Molecular Oncology, Massachusetts Institute of Technology, Cambridge, … Continue reading

Posted in Ideas | Comments Off on Natural product-derived therapy for Human cancers: Shikonin, one of the main components of herb Zicao, increases the expression of mitochondrial protein LACTB, decreases levels of mitochondrial phosphatidylserine decarboxylase, alters mitochondrial lipid metabolism, and promotes differentiation of breast cancer cells via up-regulation of its target gene, 24/March/2017, 6.37 pm

Natural product-derived Combination therapy for Squamous cell carcinoma of head and neck (HNSCC): A therapeutic mix encompassing an anticancer drug, 1,25-dihydroxyvitamin D and Luteolin may inhibit BMI1 and AP-1 expression, overcome chemotherapeutic resistance, promote chemosensitivity, suppress cancer stem cells in HNSCC, and inhibit lymph node metastasis via down regulation of its target genes , 24/March/2017, 6.04 pm

Introduction: What they say: A study from the Laboratory of Molecular Signaling, Division of Oral Biology and Medicine, Jonsson Comprehensive Cancer Center and Broad Stem Cell Research Center, UCLA, Los Angeles, California, USA shows that inhibition of BMI1+ Cancer Stem Cells Overcomes … Continue reading

Posted in Ideas | Comments Off on Natural product-derived Combination therapy for Squamous cell carcinoma of head and neck (HNSCC): A therapeutic mix encompassing an anticancer drug, 1,25-dihydroxyvitamin D and Luteolin may inhibit BMI1 and AP-1 expression, overcome chemotherapeutic resistance, promote chemosensitivity, suppress cancer stem cells in HNSCC, and inhibit lymph node metastasis via down regulation of its target genes , 24/March/2017, 6.04 pm

Natural product-derived therapy for glucose homeostasis and TIIDM: Glucoraphanin, found in broccoli, brussel sprouts, and cauliflower, increases Pax6 and insulin expression, decreases the levels of glucagon, ghrelin and Somatostatin, reduces metabolic stress, improves insulin sensitivity, promotes glucose homeostasis and prevents progression to TIIDM via down regulation of their target gene, 23/March/2017, 7. 15 pm

Introduction: What they say  A study from the Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem, Israel shows that “PAX6 maintains ß cell identity by repressing genes of alternative … Continue reading

Posted in Ideas | Comments Off on Natural product-derived therapy for glucose homeostasis and TIIDM: Glucoraphanin, found in broccoli, brussel sprouts, and cauliflower, increases Pax6 and insulin expression, decreases the levels of glucagon, ghrelin and Somatostatin, reduces metabolic stress, improves insulin sensitivity, promotes glucose homeostasis and prevents progression to TIIDM via down regulation of their target gene, 23/March/2017, 7. 15 pm

Natural product-derived therapy for Human cancers: Eriocitrin, one of the components of Lemons, increases the expression of mitochondrial protein LACTB, decreases levels of mitochondrial phosphatidylserine decarboxylase, alters mitochondrial lipid metabolism, and promotes differentiation of breast cancer cells via up-regulation of its target gene, 23/March/2017, 11.00 am

Introduction: What they say: A study from the Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts, USA Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA; MIT Ludwig Center for Molecular Oncology, Massachusetts Institute of Technology, Cambridge, … Continue reading

Posted in Ideas | Comments Off on Natural product-derived therapy for Human cancers: Eriocitrin, one of the components of Lemons, increases the expression of mitochondrial protein LACTB, decreases levels of mitochondrial phosphatidylserine decarboxylase, alters mitochondrial lipid metabolism, and promotes differentiation of breast cancer cells via up-regulation of its target gene, 23/March/2017, 11.00 am

Molecular therapy for the lost pancreatic β-cells in Diabetic patients: Valproic acid promotes an insulin-sensitized state via up-regulation of its target gene Lin-28, 23/March/2017, 8.17 pm

What we say:  Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Molecular therapy for the lost pancreatic β-cells in Diabetic patients: Valproic acid promotes an insulin-sensitized state via up-regulation of  its target gene Lin-28 From Significance of the study to Public health relevance:  … Continue reading

Posted in Ideas | Comments Off on Molecular therapy for the lost pancreatic β-cells in Diabetic patients: Valproic acid promotes an insulin-sensitized state via up-regulation of its target gene Lin-28, 23/March/2017, 8.17 pm

Natural product-derived therapy for Allergic rhinitis: Shikonin, found in Zicao/Lithospermum erythrorhizon, inhibits GM-CSF, Interleukin 13 receptor(IL-13)-Rα1, and eotaxin expression, among others, inhibits mucus production and alleviates allergic rhinitis via up regulation of its target gene, 22/March/2017, 11.37 pm

What we say: Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-derived therapy for Allergic rhinitis: Shikonin, found in Zicao/Lithospermum erythrorhizon,  inhibits GM-CSF, Interleukin 13 receptor(IL-13)-Rα1, and eotaxin expression, among others, inhibits mucus production and alleviates allergic rhinitis … Continue reading

Posted in Ideas | Comments Off on Natural product-derived therapy for Allergic rhinitis: Shikonin, found in Zicao/Lithospermum erythrorhizon, inhibits GM-CSF, Interleukin 13 receptor(IL-13)-Rα1, and eotaxin expression, among others, inhibits mucus production and alleviates allergic rhinitis via up regulation of its target gene, 22/March/2017, 11.37 pm

Molecular therapy for pulmonary fibrosis: Ethinylestradiol decreases miR-34 expression, increases Sirtuin-1 expression, suppresses tumor suppressor p53 acetylation, prevents apoptosis in Alveolar epithelial cell (AEC), and improves pulmonary fibrosis via down regulation of its target gene, 22/March/2017, 11.22 pm

What we say:  Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Molecular therapy for pulmonary fibrosis: Ethinylestradiol decreases miR-34 expression, increases Sirtuin-1 expression, suppresses tumor suppressor p53 acetylation, prevents apoptosis in Alveolar epithelial cell (AEC), and improves pulmonary fibrosis via down … Continue reading

Posted in Ideas | Comments Off on Molecular therapy for pulmonary fibrosis: Ethinylestradiol decreases miR-34 expression, increases Sirtuin-1 expression, suppresses tumor suppressor p53 acetylation, prevents apoptosis in Alveolar epithelial cell (AEC), and improves pulmonary fibrosis via down regulation of its target gene, 22/March/2017, 11.22 pm

Natural product-based Lifespan extension therapy: Catalpol activates autophagy and extends lifespan via up regulation of ATG5, 22/March/2017, 11.17 pm

Introduction: What they say A study from the Global Research Laboratory, Seoul National University, Korea shows that “Overexpression of Atg5 in mice activates autophagy and extends lifespan.” This study was published in the online journal “Nature communications” by Prof. Jung YK, Pyo Jo and others.  What we … Continue reading

Posted in Ideas | Comments Off on Natural product-based Lifespan extension therapy: Catalpol activates autophagy and extends lifespan via up regulation of ATG5, 22/March/2017, 11.17 pm

Natural product-derived therapy for Regenerating the lost pancreatic β-cells in Diabetic patients: Glycyrrhizin, isolated from Licorice (Glycyrrhiza uralensis Fischer), promotes an insulin-sensitized state via up-regulation of its target gene Lin-28, 22/March/2017, 7.19 pm

What we say:  Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-derived therapy for Regenerating the lost pancreatic β-cells in Diabetic patients:  Glycyrrhizin, isolated from Licorice (Glycyrrhiza uralensis Fischer), promotes an insulin-sensitized state via up-regulation of  its target gene Lin-28 From Significance of … Continue reading

Posted in Ideas | Comments Off on Natural product-derived therapy for Regenerating the lost pancreatic β-cells in Diabetic patients: Glycyrrhizin, isolated from Licorice (Glycyrrhiza uralensis Fischer), promotes an insulin-sensitized state via up-regulation of its target gene Lin-28, 22/March/2017, 7.19 pm

Natural product-derived therapy for Human Leukemias: Wogonin, isolated from Scutellaria baicalensis, suppresses B-Cell and myeloid leukemias via up regulation of the tumor suppressor IRF4, 22/March/2017, 6.25 pm

Introduction: What they say Noble laureate in Physiology/Medicine (1975) Prof. David Baltimore, from California Institute of Technology, California, USA, had reported in the July 8, 2014 issue of the Journal “Blood” that: “Dual mechanisms by which MiR-125b represses IRF4 to induce myeloid/B-cell leukemias.”  What we say: On the foundation of this … Continue reading

Posted in Ideas | Comments Off on Natural product-derived therapy for Human Leukemias: Wogonin, isolated from Scutellaria baicalensis, suppresses B-Cell and myeloid leukemias via up regulation of the tumor suppressor IRF4, 22/March/2017, 6.25 pm

Amino acid-based Lifespan extension therapy: L-Leucine prolongs mammalian life span via down regulation of angiotensin II type I receptor (AT1R), 22/March/2017, 9.14 am

Significance of the study: It has been shown earlier that antagonizing angiotensin II type I receptor (AT1R) expression may prolong mammalian life span. Further, it has been shown that disruption of AT1R (AGTR1) gene results in marked prolongation of mammalian lifespan.  From research … Continue reading

Posted in Ideas | Comments Off on Amino acid-based Lifespan extension therapy: L-Leucine prolongs mammalian life span via down regulation of angiotensin II type I receptor (AT1R), 22/March/2017, 9.14 am

Anti-telomerase cancer therapy: Forsythiae Fructus extract suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and the cellular immortality gene telomerase and inhibits cancer progression via down-regulation of it target gene, 22/March/2017, 7.23 am

Introduction:  The 1989 Nobel prize winner in Chemistry, Prof. Thomas R. Cech from the BioFrontiers Institute, USA has published a research paper in the 13 December 2012 issue of the Nature journal (492(7428):285-9; and I.F: >42) stating that “The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity.”  This study provides mechanistic insights into how TPP1 regulates telomerase function. … Continue reading

Posted in Ideas | Comments Off on Anti-telomerase cancer therapy: Forsythiae Fructus extract suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and the cellular immortality gene telomerase and inhibits cancer progression via down-regulation of it target gene, 22/March/2017, 7.23 am