Ideas

August 19, 2017

Natural product-based therapy for Cardiomyopathy: Geniposide, isolated from Gardenia and among others, decreases the expression of Sox6, restores the balance between slow- and fast-twitch myofiber proteins and alleviates Cardiomyopathy via up regulation of its target gene, 20/August/2017,  1.15 am

Introduction: What they say A recent study from the Department of Cardiology, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, USA; and Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, USA shows that “Trbp regulates heart […]
August 19, 2017

Natural product-based therapy for Inflammatory bowel disease(IBD): Mangiferin, isolated from Mangoes, decreases the expression of oncostatin M, attenuates activation of oncostatin M- oncostatin M receptor pathway in inflamed colon tissues, inhibits inflammatory gene expression, attenuates colonic pathogenesis, and inhibits the progression of inflammatory bowel disease and colitis via down regulation of its target gene, 20/August/2017, 12.56 am

Introduction: What they say: A study from the Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK Translational Gastroenterology Unit, Nuffield Department of Medicine, University of Oxford, […]
August 19, 2017

Molecular therapy for Metastatic cancers: Ivermectin, the anthelmintic drug, increases the expression of metastasis suppressors  PTEN and PDCD4, inhibits cell cycle progression, and suppresses migration, invasion and metastasis of cancer cells via up regulation of its target gene, 19/August/2017, 12.40 am

From Significance of the study to Public health relevance: Given that: (i) each year nearly 14 million people are diagnosed with cancer globally, and little more […]
August 19, 2017

Natural product-derived CMTM6/4-PD-L1 pathway blockade enhances the efficacy of Cancer immunotherapy: A therapeutic mix encompassing Honokiol and Magnolol, isolated from Magnolia grandiflora/dealbata/obovata/officinalis, inhibits the expression of transmembrane protein CMTM6/CMTM4, increases interferon-IFNγ signalling, augments antigen presentation and unfolding response, increases Cytotoxic activity of T-cells, decreases tumor burden and increases survival via up-regulation of its target gene, 19/August/2017, 11.58 pm

Introduction:What they say: A recent study from Division of Molecular Oncology & Immunology, The Netherlands Cancer Institute, Plesmanlaan, CX Amsterdam, The Netherlands has identified CMTM6 and […]