Category Archives: Ideas

MiRNA-based PD-1 pathway blockade for Human cancer therapy: MiR-192 inhibits the expression of co-inhibitory receptor PD-1 on Antigen- Specific T-cells, increases the production of cytokines by tumor-infiltrating lymphocytes (TIL), and draining lymph nodes and augments anti-tumor activity via down-regulation of its target gene, 4/December/2016, 9.20 pm

Introduction:What they say:   A recent study from Division of Infectious Diseases, School of Medicine, Johns Hopkins University, Baltimore, MD 21218, United States shows that “TGF-β1-Mediated Smad3 Enhances PD-1 Expression on Antigen-Specific T Cells in Cancer.” This study was published … Continue reading

Posted in Ideas | Comments Off on MiRNA-based PD-1 pathway blockade for Human cancer therapy: MiR-192 inhibits the expression of co-inhibitory receptor PD-1 on Antigen- Specific T-cells, increases the production of cytokines by tumor-infiltrating lymphocytes (TIL), and draining lymph nodes and augments anti-tumor activity via down-regulation of its target gene, 4/December/2016, 9.20 pm

Molecular therapy for Bone disorders: MiR-185 inhibits the expression of Tgif2 and suppresses osteoporosis and bone metastasis via up-regulation of its target gene, 4/December/2016, 9.01 pm

Introduction: What they say:  A study from the Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA has reported that “miR-34a blocks osteoporosis and bone metastasis by inhibiting osteoclastogenesis and Tgif2.” This study was published in the June 25, 2014 Nature  [I.F … Continue reading

Posted in Ideas | Comments Off on Molecular therapy for Bone disorders: MiR-185 inhibits the expression of Tgif2 and suppresses osteoporosis and bone metastasis via up-regulation of its target gene, 4/December/2016, 9.01 pm

Small molecule-based anti-ageing therapy: Yin Yang 1 (YY1) increases NMN levels, decreases age-associated weight gain, augments energy metabolism, improves physical activity and insulin sensitivity, promotes healthy lipid profile, and improves eye function via down regulation of its target gene, 3/December/2015, 8.01 am

Introduction: What they say A study from Gladstone Institute of Neurological Disease and Department of Neurology, University of California, San Francisco, San Francisco, CA 94158, USA and Department of Developmental Biology, Washington University School of Medicine, Saint Louis, MO 63110, … Continue reading

Posted in Ideas | Comments Off on Small molecule-based anti-ageing therapy: Yin Yang 1 (YY1) increases NMN levels, decreases age-associated weight gain, augments energy metabolism, improves physical activity and insulin sensitivity, promotes healthy lipid profile, and improves eye function via down regulation of its target gene, 3/December/2015, 8.01 am

Natural product therapy for Bone disorders: Chebulagic acid (CHA), isolated from Terminalia chebula, inhibits the expression of Tgif2 and suppresses osteoporosis and bone metastasis via up-regulation of its target gene, 3/December/2016, 7.49 pm

Introduction: What they say:  A study from the Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA has reported that “miR-34a blocks osteoporosis and bone metastasis by inhibiting osteoclastogenesis and Tgif2.” This study was published in the June 25, 2014 Nature  [I.F … Continue reading

Posted in Ideas | Comments Off on Natural product therapy for Bone disorders: Chebulagic acid (CHA), isolated from Terminalia chebula, inhibits the expression of Tgif2 and suppresses osteoporosis and bone metastasis via up-regulation of its target gene, 3/December/2016, 7.49 pm

Natural product Life-extension therapy: EHHM (E‑[6′-(5′-hydroxypentyl)tricosyl]-4-hydroxy-3-methoxycinnamate), found in Livistona Chinensis, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 3/December/2016, 5.57 pm

What they say? A study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.” This study was published in the … Continue reading

Posted in Ideas | Comments Off on Natural product Life-extension therapy: EHHM (E‑[6′-(5′-hydroxypentyl)tricosyl]-4-hydroxy-3-methoxycinnamate), found in Livistona Chinensis, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 3/December/2016, 5.57 pm

Natural product-derived antiviral therapy against chikungunya (CHIKV) and Zika (ZIKV) viruses: Kukoamine A (KuA), a spermine alkaloid derived from Cortex lycii radicis and Lycium chinense among others, decreases spermidine/spermine N1-acetyltransferase (SAT) expression, depletes spermidine and Spermine levels, and restricts Chikungunya and Zika viruses replication via up regulation of its target gene, 3/December/2015, 5.38 pm

Introduction: What they say A study from the Viral Populations and Pathogenesis Unit, Institut Pasteur, CNRS UMR 3569, 25–28 rue du Dr. Roux, 75724 Paris Cedex 15, France shows that “Interferon-Induced Spermidine-Spermine Acetyltransferase and Polyamine Depletion Restrict Zika and Chikungunya … Continue reading

Posted in Ideas | Comments Off on Natural product-derived antiviral therapy against chikungunya (CHIKV) and Zika (ZIKV) viruses: Kukoamine A (KuA), a spermine alkaloid derived from Cortex lycii radicis and Lycium chinense among others, decreases spermidine/spermine N1-acetyltransferase (SAT) expression, depletes spermidine and Spermine levels, and restricts Chikungunya and Zika viruses replication via up regulation of its target gene, 3/December/2015, 5.38 pm

Natural product-derived therapy for Myocardial Infarction: Guggulsterone (4,17(20)-pregnadiene-3,16-dione), a resin found in the Guggul herb Commiphora mukul, inhibits DNA damage responses, and telomere shortening, and promotes cardiomyocyte survival after myocardial infarction via up-regulation of PNUTS, 3/December/2016, 6.55 am

What they say:  A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published in the 7 March  2013 issue of Nature  by Prof Dimmler, Boon, and others. What we say:  On the foundation of this interesting finding, Dr L Boominathan … Continue reading

Posted in Ideas | Comments Off on Natural product-derived therapy for Myocardial Infarction: Guggulsterone (4,17(20)-pregnadiene-3,16-dione), a resin found in the Guggul herb Commiphora mukul, inhibits DNA damage responses, and telomere shortening, and promotes cardiomyocyte survival after myocardial infarction via up-regulation of PNUTS, 3/December/2016, 6.55 am

Natural product Life-span extension therapy: Ferulic acid, found abundantly in the flax seeds, refined maize bran and soft and hard rice bran among others, may increase life span by suppressing mTOR pathway, 2/December/2016, 11.27 pm

What is known:  It has been shown earlier that decreasing the expression/activity of mTOR increases overall mammalian lifespan, suggesting that mTOR inhibitors may function as “longevity promoters.” I have published recently that Ferulic acid promotes cardiomyocyte survival and prevents myocardial ageing … Continue reading

Posted in Ideas | Comments Off on Natural product Life-span extension therapy: Ferulic acid, found abundantly in the flax seeds, refined maize bran and soft and hard rice bran among others, may increase life span by suppressing mTOR pathway, 2/December/2016, 11.27 pm

Natural product-derived cardioprotective therapy: 2,3,5,4′-tetrahydroxystilbene-2-O-β-D-glucoside, the main component of Polygonum multiflorum thunb, increases Spermidine levels, augments autophagy, mitophagy and mitochondrial respiration, lowers systemic blood pressure, protects it from cardiac diseases and promotes longevity via down regulation of its target gene, 2/December/2016, 7.31 pm

Introduction: What they say A study from the Institute of Molecular Biosciences, University of Graz, Humboldtstraße 50, A-8010 Graz shows that “Cardioprotection and lifespan extension by the natural polyamine spermidine.” This research paper was published in the 14 November 2016 … Continue reading

Posted in Ideas | Comments Off on Natural product-derived cardioprotective therapy: 2,3,5,4′-tetrahydroxystilbene-2-O-β-D-glucoside, the main component of Polygonum multiflorum thunb, increases Spermidine levels, augments autophagy, mitophagy and mitochondrial respiration, lowers systemic blood pressure, protects it from cardiac diseases and promotes longevity via down regulation of its target gene, 2/December/2016, 7.31 pm

Natural product-derived anti-ageing therapy: Shikonin, the major component of Zicao (also known as purple gromwell, the dried root of Lithospermum erythrorhizon), activates autophagy and extend lifespan via up regulation of its target gene, 2/December/2016, 7.14 pm

What we say: Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports here that: Shikonin, the major component of Zicao (also known as purple gromwell, the dried root of Lithospermum erythrorhizon),  activates autophagy and extend lifespan via up regulation of its target … Continue reading

Posted in Ideas | Comments Off on Natural product-derived anti-ageing therapy: Shikonin, the major component of Zicao (also known as purple gromwell, the dried root of Lithospermum erythrorhizon), activates autophagy and extend lifespan via up regulation of its target gene, 2/December/2016, 7.14 pm

Natural product-derived therapy for triple-negative breast tumors: Withaferin A, isolated from Withania somnifera/Ashwagandha and Acnistus arborescens among others, increases the levels of cell cycle inhibitor, p27, inhibits pro-survival pathways mediated by c-Myc, and inhibits the progression of triple-negative breast cancer via up-regulation of its target gene, 2/December/2015, 6.32 pm

Introduction: What they say A study from the Department of Cell and Tissue Biology, University of California, San Francisco (UCSF), San Francisco, California, USA shows that “PIM1 kinase inhibition as a targeted therapy against triple-negative breast tumors with elevated MYC … Continue reading

Posted in Ideas | Comments Off on Natural product-derived therapy for triple-negative breast tumors: Withaferin A, isolated from Withania somnifera/Ashwagandha and Acnistus arborescens among others, increases the levels of cell cycle inhibitor, p27, inhibits pro-survival pathways mediated by c-Myc, and inhibits the progression of triple-negative breast cancer via up-regulation of its target gene, 2/December/2015, 6.32 pm

Natural product-derived therapy for Myocardial Infarction: Emodin (6-methyl-1,3,8-trihydroxy anthraquinone), found in Polygonum multiflorum, and Japanese knotweed among others, inhibits DNA damage responses, and telomere shortening, and promotes cardiomyocyte survival after myocardial infarction via up-regulation of PNUTS, 2/December/2016, 12.15 pm

What they say:  A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published in the 7 March  2013 issue of Nature  by Prof Dimmler, Boon, and others. What we say:  On the foundation of this interesting finding, Dr L Boominathan … Continue reading

Posted in Ideas | Comments Off on Natural product-derived therapy for Myocardial Infarction: Emodin (6-methyl-1,3,8-trihydroxy anthraquinone), found in Polygonum multiflorum, and Japanese knotweed among others, inhibits DNA damage responses, and telomere shortening, and promotes cardiomyocyte survival after myocardial infarction via up-regulation of PNUTS, 2/December/2016, 12.15 pm

Lifespan extension therapy: Lithocholic acid (LCA) activates autophagy and extend lifespan via up regulation of its target gene, 2/December/2016, 7.04am

What we say: Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports here that:  Lifespan extension therapy: Lithocholic acid (LCA) activates autophagy and extends lifespan via up regulation of its target gene From Significance of the study to Therapeutic opportunity: This study suggests, … Continue reading

Posted in Ideas | Comments Off on Lifespan extension therapy: Lithocholic acid (LCA) activates autophagy and extend lifespan via up regulation of its target gene, 2/December/2016, 7.04am

Molecular therapy for Metabolic disorders: PNUTS (a protein phosphatase) increases (LXR)-α expression, insulin-secreting cell mass and function via down regulation of its target genes, 2/December/2016, 7.01 am

Public health relevance:  Given that (1)  more than 387 million people worldwide are affected by Diabetes mellitus (DM); (2) the life-long painful injection/drug treatment required to treat DM; and (3) the global economic cost spent for diabetes treatment in 2014 was … Continue reading

Posted in Ideas | Comments Off on Molecular therapy for Metabolic disorders: PNUTS (a protein phosphatase) increases (LXR)-α expression, insulin-secreting cell mass and function via down regulation of its target genes, 2/December/2016, 7.01 am

Natural product-derived antiviral therapy against chikungunya (CHIKV) and Zika (ZIKV) viruses: Cucurbitacin E, found abundantly in Watermelons, decreases spermidine/spermine N1-acetyltransferase (SAT1) expression, depletes spermidine and Spermine levels, and restricts Chikungunya and Zika viruses replication via up regulation of its target gene, 1/December/2015, 8.13 pm

Introduction: What they say A study from the Viral Populations and Pathogenesis Unit, Institut Pasteur, CNRS UMR 3569, 25–28 rue du Dr. Roux, 75724 Paris Cedex 15, France shows that “Interferon-Induced Spermidine-Spermine Acetyltransferase and Polyamine Depletion Restrict Zika and Chikungunya … Continue reading

Posted in Ideas | Comments Off on Natural product-derived antiviral therapy against chikungunya (CHIKV) and Zika (ZIKV) viruses: Cucurbitacin E, found abundantly in Watermelons, decreases spermidine/spermine N1-acetyltransferase (SAT1) expression, depletes spermidine and Spermine levels, and restricts Chikungunya and Zika viruses replication via up regulation of its target gene, 1/December/2015, 8.13 pm

Natural product-based cardioprotective therapy: Lycium barbarum polysaccharide (LBP) increases Spermidine levels, augments autophagy, mitophagy and mitochondrial respiration, lowers systemic blood pressure, and protects it from cardiac diseases via down regulation of its target gene, 1/December/2016, 2.40 pm

Introduction: What they say A study from the Institute of Molecular Biosciences, University of Graz, Humboldtstraße 50, A-8010 Graz shows that “Cardioprotection and lifespan extension by the natural polyamine spermidine.” This research paper was published in the 14 November 2016 … Continue reading

Posted in Ideas | Comments Off on Natural product-based cardioprotective therapy: Lycium barbarum polysaccharide (LBP) increases Spermidine levels, augments autophagy, mitophagy and mitochondrial respiration, lowers systemic blood pressure, and protects it from cardiac diseases via down regulation of its target gene, 1/December/2016, 2.40 pm

Natural product-derived Lifespan extension therapy: EHHM, a natural product found in Livistona chinensis, activates autophagy and extend lifespan via up regulation of its target gene, 1/December/2016, 12.20 pm

What we say: On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-derived Lifespan extension therapy: EHHM, a natural product found in Livistona chinensis, activates autophagy and extends lifespan via up regulation of its target gene From … Continue reading

Posted in Ideas | Comments Off on Natural product-derived Lifespan extension therapy: EHHM, a natural product found in Livistona chinensis, activates autophagy and extend lifespan via up regulation of its target gene, 1/December/2016, 12.20 pm

Natural product-derived therapy for Myocardial Infarction: Ferulic acid, found abundantly in the flax seeds, refined maize bran and soft and hard rice bran among others, inhibits DNA damage responses, and telomere shortening, and promotes cardiomyocyte survival after myocardial infarction via up-regulation of PNUTS, 1/December/2016, 9.40 am

What they say:  A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published in the 7 March  2013 issue of Nature  by Prof Dimmler, Boon, and others. What we say:  On the foundation of this interesting finding, Dr L Boominathan … Continue reading

Posted in Ideas | Comments Off on Natural product-derived therapy for Myocardial Infarction: Ferulic acid, found abundantly in the flax seeds, refined maize bran and soft and hard rice bran among others, inhibits DNA damage responses, and telomere shortening, and promotes cardiomyocyte survival after myocardial infarction via up-regulation of PNUTS, 1/December/2016, 9.40 am

Life-extension therapy: JunB inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 1/December/2016, 6.07 am

What they say? A recent study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.” This study was published in … Continue reading

Posted in Ideas | Comments Off on Life-extension therapy: JunB inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 1/December/2016, 6.07 am

Cardiac rejuvenation therapy: SNAI1 , a positive regulator of epithelial-mesenchymal transitions, suppresses tumor suppressor INK4a/p16 expression, and inhibits dilated cardiomyopathy and heart failure via up regulation of its target gene, 30/November/2015, 11.14 pm

Introduction: What they say A recent study from the Stem Cell Aging Group, Centro Nacional de Investigaciones Cardiovasculares, E-28029 Madrid, Spain shows that “Bmi1 limits dilated cardiomyopathy and heart failure by inhibiting cardiac senescence.” This study was published in the online journal 9 March  2015 issue of Nature Communications by Prof Gonzalez, Gonzalez-Valdes and others. What … Continue reading

Posted in Ideas | Comments Off on Cardiac rejuvenation therapy: SNAI1 , a positive regulator of epithelial-mesenchymal transitions, suppresses tumor suppressor INK4a/p16 expression, and inhibits dilated cardiomyopathy and heart failure via up regulation of its target gene, 30/November/2015, 11.14 pm