Ideas

December 11, 2017

Lifespan extension therapy: Kaempferol, isolated from Aloe vera and Ivy Guard/Coccinia grandis,  may increase life span via up-regulation of its target gene BubR1, 12/December/2017, 1.10 am

 What they say: Introduction:  A recent study from the Department of Genetics, Paul F. Glenn Laboratories for the Biological Mechanisms of Aging Harvard Medical School, Boston,USA; and […]
December 11, 2017

Natural product-based therapy for Diabetic retinopathy: Sulforaphane, isolated from Broccoli, among others, inhibits Soluble epoxide hydrolase (sEH) expression, decreases toxic 19,20-dihydroxydocosapentaenoic acid levels, inhibits pericyte loss, vascular permeability, and inflammation of the eye and progression of diabetic retinopathy, via down regulation of its target gene, 12/December/2017, 12.07 am

Introduction: What they say A study from the Institute for Vascular Signalling, Centre for Molecular Medicine, Goethe University, Frankfurt am Main, Germany; and German Centre for […]
December 11, 2017

Molecular therapy for Non-alcoholic fatty liver disease (NAFLD): Trimetazidine (TMZ)[brand names: 3 Kat, Adexor, Aiyiling, Angimax, Angimet, Anginox, Angintriz, Angiozil, Angirel etc., ], used in the treatment of angina pectoris,  promotes degradation of HMGCR, decreases the levels of triglycerides, free cholesterol, and total cholesterol and prevents the progression of Non-alcoholic fatty liver disease (NAFLD via down regulation of its target gene, 11/December/2017, 10.58 pm

Significance of the study: Given that: (1)  15-30% of Western populations suffer from Non-alcoholic fatty liver disease (NAFLD), while only 6-25% of Asian populations suffer from it; […]
December 11, 2017

Molecular therapy for body weight control, energy homeostasis and TIIDM: Glimepiride (Brand name: Amaryl), an anti-hyperglycemic medication,  inhibits DNA methyltransferase 3a (Dnmt3a) expression, increases FGF21 expression, augments insulin sensitivity, increases glucose tolerance, and protects from diet-induced obesity and TIIDM, via up regulation of its target gene, 11/December/2017, 10.41 pm

Introduction: What they say A study from Nutritional Sciences and Toxicology Department, University of California, Berkeley, Berkeley, United States shows that “Dnmt3a is an epigenetic mediator […]