Ideas

A derivative of Estrone comes to the rescue of anxiety and depression: Hydroxyestrone (16αOHE), a derivative of weak female reproductive steroid hormone Estrone, decreases PHF8 levels, increases the expression of serotonin receptors Htr1a and Htr2a, and promotes resistance to stress-induced -anxiety and -depression, via down-regulation of its target gene, 21/September/2018, 4.56 am
A derivative of Estrone comes to the rescue of anxiety and depression: Hydroxyestrone (16αOHE), a derivative of weak female reproductive steroid hormone Estrone, decreases PHF8 levels, increases the expression of serotonin receptors Htr1a and Htr2a, and promotes resistance to stress-induced -anxiety and -depression, via down-regulation of its target gene, 21/September/2018, 4.56 am 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say:  A study from Department of Molecular Biology, Cancer Center and Center for Regenerative Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA; Department of Stem Cell and…

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Awakening the sleeping/cancer-protecting angels in mutant p53-expressing human tumors: PCGF2/Mel-18 increases the expression of tumor suppressors genes, such as  SMAD7, p12DOC1/CDK2AP1,  INK4a/ARF, TA-p73, TA-p63, p53, and others, induces regression of p53-mutated human tumors, via down-regulation of its target gene, 18/September/2018, 9.05 pm
Awakening the sleeping/cancer-protecting angels in mutant p53-expressing human tumors: PCGF2/Mel-18 increases the expression of tumor suppressors genes, such as  SMAD7, p12DOC1/CDK2AP1,  INK4a/ARF, TA-p73, TA-p63, p53, and others, induces regression of p53-mutated human tumors, via down-regulation of its target gene, 18/September/2018, 9.05 pm 960 720 Dr Boomi's Genom-2-Discovery Center

From Significance of the study to Public health relevance:  Given that: (1) cancer suppressor p53 is mutated in more than 50% of human cancers of different tissue origin; (2) p53…

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Turning to Probiotics may boost memory, learning and cognition:  Probiotic Lactobacillus Plantarum increases Tissue inhibitor of metalloproteinases 2 (TIMP2) levels, improves cognition, and decreases age-associated decline in memory and learning via down-regulation of its target genes, 18/September/2018, 8.50 pm
Turning to Probiotics may boost memory, learning and cognition:  Probiotic Lactobacillus Plantarum increases Tissue inhibitor of metalloproteinases 2 (TIMP2) levels, improves cognition, and decreases age-associated decline in memory and learning via down-regulation of its target genes, 18/September/2018, 8.50 pm 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A study from Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California 94305, USA;  Paul F. Glenn Center for the Biology of…

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Awakening the sleeping/cancer-protecting angels in mutant p53-expressing human tumors: Andrographolide, isolated from Andrographis paniculata, increases the expression of tumor suppressors genes, such as TPM1, PDCD4, p53,  p53, TAp63, TAp73, INK4a/ARF, and others, induces regression of p53-mutated human tumors, via down-regulation of its target gene, 18/September/2018, 2.19 pm
Awakening the sleeping/cancer-protecting angels in mutant p53-expressing human tumors: Andrographolide, isolated from Andrographis paniculata, increases the expression of tumor suppressors genes, such as TPM1, PDCD4, p53,  p53, TAp63, TAp73, INK4a/ARF, and others, induces regression of p53-mutated human tumors, via down-regulation of its target gene, 18/September/2018, 2.19 pm 960 720 Dr Boomi's Genom-2-Discovery Center

From Significance of the study to Public health relevance:  Given that: (1) cancer suppressor p53 is mutated in more than 50% of human cancers of different tissue origin; (2) p53…

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A cup of probiotic a day keeps cardiac diseases at bay: Probiotic Lactobacillus casei Zhang inhibits DNA damage responses, induces telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte survival after myocardial infarction, via up-regulation of PNUTS, 18/September/2018, 8.16 am
A cup of probiotic a day keeps cardiac diseases at bay: Probiotic Lactobacillus casei Zhang inhibits DNA damage responses, induces telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte survival after myocardial infarction, via up-regulation of PNUTS, 18/September/2018, 8.16 am 960 720 Dr Boomi's Genom-2-Discovery Center

What they say:  A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac aging and function.” This study was published, in the 7 March  2013 issue of the journal Nature,  by Prof Dimmler, Boon, and…

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Mechanistic insights into how a known anesthetic drug functions as an analgesic agent: Levobupivacaine (brand name: Chirocaine),  a local anesthetic drug, increases the expression of PD-L1, attenuates acute and chronic pain, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability, via up-regulation of its target gene, 18/September/2018, 7.56 am
Mechanistic insights into how a known anesthetic drug functions as an analgesic agent: Levobupivacaine (brand name: Chirocaine),  a local anesthetic drug, increases the expression of PD-L1, attenuates acute and chronic pain, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability, via up-regulation of its target gene, 18/September/2018, 7.56 am 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say: A recent study from Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center for Brain Science, Fudan University,…

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