Ideas

November 14, 2018

Molecular therapy for aging-associated diseases and Lifespan extension: Rosuvastatin, an anti-dyslipidemic drug used to treat lower cholesterol levels and cardiovascular disease,, increases NMN/NAD levels, decreases interaction of DBC1 with PARP1, increases PARP1 activity, promotes DNA repair, augments tolerance against radiation, cancer and aging via down regulation of its target gene, 14/November/2018, 11.48 pm

Introduction: What they say A study from Department of Genetics, Paul F. Glenn Center for the Biology of Aging, Harvard Medical School, Boston, MA, USA; and […]
November 14, 2018

Astrocyte-derived neurotrophic factor comes to the rescue of Diabetes Mellitus: MANF (Mesencephalic astrocyte-derived neurotrophic factor) augments the expression of FGF19 and FGF1,  attenuates hepatic glucose production, decreases hepatic acetyl CoA content, brings down the levels of plasma ACTH, and corticosterone, augments insulin sensitivity, promotes weight loss and alleviates TIDM via upregulation of its target gene, 14/October/2018, 3.38 pm

Introduction: What they say  A study from Diabetes and Obesity Center of Excellence, Department of Medicine, University of Washington, Seattle, Washington, USA shows that Central injection […]
November 14, 2018

Mechanistic insights into how ADNP enhances learning, memory and cognition: ADNP (Activity-dependent neuroprotective protein) increases Tissue inhibitor of metalloproteinases 2 (TIMP2) levels, improves cognition, and decreases age-associated decline in memory and learning, via down-regulation of its target genes, 14/November/2018, 3.20 pm

Introduction: What they say: A study from Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California 94305, USA;  Paul F. Glenn Center […]
November 14, 2018

Molecular therapy for Regenerating the lost pancreatic β-cells in Diabetic patients: MANF (Mesencephalic astrocyte-derived neurotrophic factor)  increases the expression of IGF1R, INSR, and IRS2, and promotes an insulin-sensitized state via up-regulation of  its target gene Lin28, 14/November/2018, 3.11 pm

Introduction: What they say:   A study from the Stem Cell Transplantation Program, Division of Pediatric Hematology/Oncology, Boston Children’s Hospital and Dana-Farber Cancer Institute, Boston, Massachusetts, USA shows that “The Lin28/let-7 axis […]
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